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TLR6 Knockout Cell Lines

Gene: TLR6

Official Full Name: toll like receptor 6provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31972 TLR6 Knockout cell line (HeLa) Human TLR6 1:3~1:6 Negative Online Inquiry
KO31973 TLR6 Knockout cell line (HCT 116) Human TLR6 1:2~1:4 Negative Online Inquiry
KO31974 TLR6 Knockout cell line (A549) Human TLR6 1:3~1:4 Negative Online Inquiry

Background

TLR6 Gene Knockout Cell Lines are specially engineered cellular models that have undergone a targeted disruption of the TLR6 gene, a crucial component in the innate immune response. These cell lines facilitate comprehensive studies of Toll-like receptor (TLR) signaling pathways, particularly those involving TLR6's role in recognizing microbial components and modulating host immune responses. By eliminating the TLR6 gene, researchers can elucidate the specific contributions of this receptor to the broader immune landscape, as well as its interactions with other TLRs and immune mediators.

The primary function of TLR6 is to bind to a diverse array of microbial molecules, initiating signaling cascades that culminate in the activation of immune cells. This process leads to the production of pro-inflammatory cytokines and the activation of adaptive immunity. TLR6 Gene Knockout Cell Lines allow scientists to dissect these pathways in a controlled environment, providing invaluable insights into their mechanisms and the relative contributions of TLR6 to various immune responses.

In research and clinical settings, the TLR6 knockout cell lines provide a powerful tool for investigating diseases characterized by dysregulated immune responses, such as autoimmune disorders, chronic infections, and even cancer. By using these cell lines, researchers can probe the role of TLR6 in specific contexts, paving the way for novel therapeutic strategies.

What sets our TLR6 Gene Knockout Cell Lines apart from alternatives is their rigorous validation and characterization, ensuring their accuracy and reliability in experimental applications. Unlike other knockout models that may exhibit off-target effects, our products are developed using advanced genome editing technologies, yielding precise modifications with high efficiency.

For researchers and clinicians focused on the immune system, these cell lines are essential for advancing knowledge in immunology and therapeutic development. Our company prides itself on its commitment to excellence and innovation in biological research products, ensuring that our offerings not only meet but exceed the expectations of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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