Gene: TLL1
Official Full Name: tolloid like 1provided by HGNC
Gene Summary: This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13382 | TLL1 Knockout cell line (HeLa) | Human | TLL1 | 1:3~1:6 | Negative | Online Inquiry |
TLL1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the TLL1 gene, which codes for the enzyme Tolloid-like 1. This innovative product facilitates in-depth research into the biological functions of TLL1, including its roles in extracellular matrix modulation, development, and disease pathology. By wholly eliminating TLL1 expression, researchers can explore the downstream effects on signaling pathways and gene expression, unraveling the gene's contribution to various physiological and pathological processes.
The primary functionality of TLL1 Gene Knockout Cell Lines lies in their ability to serve as a model system for studying gene function and cellular behavior in the absence of the TLL1 protein. These cell lines provide researchers with a robust tool to elucidate mechanistic insights into processes like tissue remodeling and tumorigenesis, where TLL1 might play a pivotal role. Moreover, by utilizing CRISPR/Cas9 technology for the knockout creation, these cell lines guarantee precise edits, fostering further downstream applications in functional genomics and drug discovery.
From a scientific standpoint, TLL1 Gene Knockout Cell Lines hold immense value in both research and clinical contexts. In academic laboratories, they facilitate cutting-edge investigations into gene regulation and protein functions. Clinically, understanding TLL1's interactions could lead to breakthroughs in developing targeted therapies for conditions related to aberrant extracellular matrix remodeling.
What sets TLL1 Gene Knockout Cell Lines apart from alternative models is their specific gene targeting, combined with a proven track record of stability and reproducibility. Unlike conventional knockdown methodologies that only partially reduce gene expression, our knockout variant provides a complete absence of TLL1, which enhances data reliability and validity in experimental results.
Investing in TLL1 Gene Knockout Cell Lines is crucial for researchers and clinicians aiming to uncover the complexities of genetic interactions and their implications in health and disease. Their deployment in laboratories will significantly advance the understanding of TLL1-related mechanisms.
Backed by our extensive expertise in molecular biology and synthetic genomics, we offer TLL1 Gene Knockout Cell Lines as part of our comprehensive portfolio of genetic tools designed for innovative research applications. Our commitment to quality and scientific advancement positions us as leaders in the field, ensuring that you receive unparalleled support in your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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