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TIMM21 Knockout Cell Lines

Gene: TIMM21

Official Full Name: translocase of inner mitochondrial membrane 21provided by HGNC

Gene Summary: Involved in mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly; and protein import into mitochondrial matrix. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27177 TIMM21 Knockout cell line (HeLa) Human TIMM21 1:3~1:6 Negative Online Inquiry
KO27178 TIMM21 Knockout cell line (HCT 116) Human TIMM21 1:2~1:4 Negative Online Inquiry
KO27179 TIMM21 Knockout cell line (HEK293) Human TIMM21 1:3~1:6 Negative Online Inquiry
KO27180 TIMM21 Knockout cell line (A549) Human TIMM21 1:3~1:4 Negative Online Inquiry

Background

TIMM21 Gene Knockout Cell Lines represent a revolutionary advancement in genetic research, specifically designed to facilitate the study of mitochondrial biogenesis and function by eliminating the TIMM21 gene. TIMM21, a pivotal component of the mitochondrial translocase complex, plays a crucial role in the transport of precursor proteins into mitochondria, thereby impacting cellular energy metabolism and apoptosis. These knockout cell lines allow researchers to explore the molecular mechanisms underlying mitochondrial dynamics, enabling deeper insights into both normal physiology and pathological states such as neurodegenerative diseases and metabolic disorders.

The functionality of TIMM21 Gene Knockout Cell Lines lies in their ability to provide a controlled environment for the assessment of alterations in mitochondrial function, protein import, and cellular metabolism. Researchers can observe the resultant metabolic shifts and identify compensatory pathways that may become activated in the absence of TIMM21. This makes the cell lines especially valuable in exploring how disruptions in mitochondrial import mechanisms influence cellular homeostasis and disease processes.

This product boasts significant scientific importance, as it opens new avenues for research in mitochondrial biology, drug development, and therapeutic interventions. In clinical settings, these knockout cell lines help elucidate disease mechanisms, potentially leading to the identification of new therapeutic targets for diseases linked with mitochondrial dysfunction.

Compared to traditional model organisms or unmodified cell lines, TIMM21 Gene Knockout Cell Lines provide a more precise and efficient means of studying mitochondrial biology, minimizing background noise from other genetic variables. Their use enhances reproducibility and enables targeted experimental designs that can yield clearer insights into cellular mechanisms.

Researchers and clinicians benefit significantly from this product, as it fosters innovation in experimental design and enhances the quality of research findings. The generation of reliable data from TIMM21 knockout models not only accelerates scientific discovery but also aids in the translation of findings from bench to bedside.

As a leader in biological product development, our company is committed to advancing scientific knowledge through quality offerings like TIMM21 Gene Knockout Cell Lines. Our expertise in genetic tools ensures that our products not only meet but exceed research needs, facilitating breakthroughs in biological research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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