Gene: THSD7A
Official Full Name: thrombospondin type 1 domain containing 7Aprovided by HGNC
Gene Summary: The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27321 | THSD7A Knockout cell line (A549) | Human | THSD7A | 1:3~1:4 | Negative | Online Inquiry |
THSD7A Gene Knockout Cell Lines are genetically engineered cell lines wherein the THSD7A gene has been inactivated or "knocked out." This specific genetic manipulation allows researchers to study the phenotypic changes that occur as a result of the absence of this gene, which is linked to several pathological conditions, including certain types of cancer and fibrotic diseases. By providing a model system that accurately mimics the gene's dysfunction, these cell lines facilitate extensive research into the role of THSD7A in cellular processes such as adhesion, migration, and signaling pathways, which are crucial for understanding tumor biology and tissue repair mechanisms.
The primary mechanism of action in these knockout cell lines involves the CRISPR-Cas9 gene-editing technology, which enables precise targeting and disruption of the THSD7A gene. This allows for high specificity in gene editing, reducing off-target effects and enhancing the reliability of experimental outcomes. Researchers can utilize these cell lines for various applications, including drug screening, gene function studies, and investigating the underlying mechanisms of THSD7A-related diseases.
One of the significant advantages of using THSD7A Gene Knockout Cell Lines over traditional wild-type cell lines is their potential to yield clearer insights into the gene's role in disease pathology. These knockout models provide a more relevant context for testing therapeutics that target the THSD7A pathway, ultimately enhancing the translational potential of findings from the laboratory to clinical settings. Furthermore, these cell lines are valuable tools in personalized medicine, allowing clinicians to develop targeted treatment strategies based on specific genetic abnormalities.
Our commitment to advancing scientific research is reflected in our expertise in producing high-quality genetic models and supporting tools. We are dedicated to providing researchers and clinicians with reliable products like the THSD7A Gene Knockout Cell Lines, which are integral to overcoming challenges in gene-related research and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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