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THSD4 Knockout Cell Lines

Gene: THSD4

Official Full Name: thrombospondin type 1 domain containing 4provided by HGNC

Gene Summary: Predicted to enable hydrolase activity. Predicted to be an extracellular matrix structural constituent. Involved in microfibril assembly. Located in microfibril. Implicated in thoracic aortic aneurysm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13410 THSD4 Knockout cell line (HeLa) Human THSD4 1:3~1:6 Negative Online Inquiry
KO13411 THSD4 Knockout cell line (HCT 116) Human THSD4 1:2~1:4 Negative Online Inquiry
KO13412 THSD4 Knockout cell line (HEK293) Human THSD4 1:3~1:6 Negative Online Inquiry
KO13413 THSD4 Knockout cell line (A549) Human THSD4 1:3~1:4 Negative Online Inquiry

Background

THSD4 Gene Knockout Cell Lines are invaluable biological tools generated through advanced genome editing techniques, specifically designed to disrupt the THSD4 gene, which encodes the protein thrombospondin type 1 domain-containing 4. This product is essential for researchers aiming to elucidate the functional roles of THSD4 in various biological processes, including cell adhesion, migration, and proliferation. The knockout approach allows for a controlled study of gene function by creating a cellular environment where the target protein's influence is eliminated, thereby illuminating its contributions to pathophysiological conditions.

These cell lines operate through a well-characterized mechanism where the CRISPR-Cas9 or equivalent gene editing methodology introduces targeted mutations, leading to the cessation of THSD4 expression. This loss of function can significantly aid in understanding the involvement of THSD4 in cancer biology, vascular biology, and developmental processes. By utilizing these knockout cell lines, researchers can explore THSD4’s role in cellular signaling pathways and its implications in various disease states, thus harnessing the potential for impactful discoveries in both academic and clinical research environments.

The scientific importance of THSD4 Gene Knockout Cell Lines cannot be overstated, as they provide a platform for drug discovery and molecular research, potentially facilitating the development of novel therapeutic strategies. Compared to traditional cell line models, which may retain the function of the target gene, these knockout lines offer specificity and reliability, thereby enhancing experimental reproducibility and the validity of research findings.

Advantages of using THSD4 knockout cell lines include their progressive interference with THSD4-related pathways, leading to more profound insights into genetic contributions to diseases. Additionally, these knockout models present a strategic advantage for high-throughput screening assays, making them appealing for laboratories seeking efficient and innovative solutions to complex biological questions.

Investing in THSD4 Gene Knockout Cell Lines empowers researchers and clinicians to drive advances in genetic research and therapeutic development. Our company prides itself on its commitment to providing high-quality, cutting-edge biological products, underpinned by a solid foundation of scientific expertise and innovation. Through our offerings, we strive to empower researchers to push the boundaries of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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