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THOC6 Knockout Cell Lines

Gene: THOC6

Official Full Name: THO complex subunit 6provided by HGNC

Gene Summary: This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13416 THOC6 Knockout cell line (HeLa) Human THOC6 1:3~1:6 Negative Online Inquiry
KO13417 THOC6 Knockout cell line (HCT 116) Human THOC6 1:2~1:4 Negative Online Inquiry
KO13418 THOC6 Knockout cell line (HEK293) Human THOC6 1:3~1:6 Negative Online Inquiry
KO13419 THOC6 Knockout cell line (A549) Human THOC6 1:3~1:4 Negative Online Inquiry

Background

THOC6 Gene Knockout Cell Lines are genetically modified cell lines in which the THOC6 gene—essential for mRNA export and processing—has been inactivated. This innovative product serves as a valuable tool for researchers studying the roles of the THOC6 protein in cellular processes, particularly those associated with gene expression regulation and RNA metabolism. By utilizing CRISPR-Cas9 technology, the knockout of THOC6 facilitates the exploration of its function in various biological contexts, providing insights into transcriptional regulation and protein synthesis.

The primary function of these cell lines is to elucidate the mechanisms by which THOC6 influences gene expression and cellular responses. The inactivation of THOC6 disrupts normal mRNA export pathways, allowing researchers to assess the resultant effects on gene expression profiles, cell proliferation, and stress responses. This is particularly relevant in studies focused on diseases linked to dysregulated RNA processing, such as cancer and neurodegenerative disorders.

Scientifically, THOC6 Gene Knockout Cell Lines offer significant applications in both basic and applied research settings. They provide a platform for drug discovery, where potential therapeutic agents can be screened for their effects on mRNA regulation in genetically manipulated cells. Furthermore, these knockout lines are invaluable in functional genomics studies aimed at identifying downstream targets and pathways affected by THOC6 deficiency.

What sets our THOC6 Gene Knockout Cell Lines apart from alternative products is the precision of our gene editing technique and the rigorous validation process employed to confirm successful knockout. While many cell lines may not adequately reflect the biological consequences of gene modification, ours have been thoroughly characterized, ensuring reliable experimental outcomes that researchers can trust.

For researchers and clinicians seeking to advance their understanding of mRNA dynamics and its implications in health and disease, these knockout cell lines represent a cutting-edge resource that streamlines investigation into THOC6's biological role. Our company's expertise in gene editing and a commitment to high-quality biological products further bolster our offering, solidifying our position as a leader in the field of molecular biology research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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