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THBS1 Knockout Cell Lines

Gene: THBS1

Official Full Name: thrombospondin 1provided by HGNC

Gene Summary: The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11448 THBS1 Knockout cell line (HeLa) Human THBS1 1:3~1:6 Negative Online Inquiry
KO11449 THBS1 Knockout cell line (HCT 116) Human THBS1 1:2~1:4 Negative Online Inquiry
KO11450 THBS1 Knockout cell line (A549) Human THBS1 1:3~1:4 Negative Online Inquiry

Background

THBS1 Gene Knockout Cell Lines are genetically modified cell lines designed to facilitate the study of the thrombospondin-1 (THBS1) gene and its role in various biological processes. By utilizing CRISPR-Cas9 technology, these cell lines effectively disrupt the expression of THBS1, providing researchers with a valuable tool to investigate the gene's function in cell adhesion, migration, and extracellular matrix interactions, critical for understanding tumorigenesis and angiogenesis.

The key function of THBS1 is its involvement in regulating cellular behavior through the modulation of signaling pathways associated with cellular proliferation and tissue remodeling. With these knockout cell lines, researchers can examine the phenotypic consequences of THBS1 deficiency, allowing for insights into mechanisms underlying pathological conditions, including cancer metastasis and cardiovascular diseases. The ability to elucidate these pathways is essential for developing targeted therapies and innovative strategies in treatment.

The scientific importance of THBS1 Gene Knockout Cell Lines extends to both basic and applied research settings. They can be particularly useful for drug discovery and testing, where evaluating the effects of compounds in a THBS1-deficient background can provide informative data regarding efficacy and mechanism. Moreover, the cell lines serve as an invaluable resource for laboratories focused on the investigation of cell signaling, immunology, and regenerative medicine.

What sets our THBS1 Gene Knockout Cell Lines apart from other products is their high specificity and efficiency in gene disruption, coupled with comprehensive support documentation to ensure optimal experimental design. In addition, these cell lines are validated for different applications, providing researchers with confidence in reproducibility and results.

Investing in THBS1 Gene Knockout Cell Lines means gaining access to a powerful resource that streamlines research efforts and accelerates the path from basic science to clinical applications. Our commitment to quality and innovation reflects our extensive expertise in producing biologically relevant tools that empower the scientific community to achieve breakthrough discoveries. With our industry-leading solutions, we strive to support researchers and clinicians tackling some of the most challenging biological questions.

Please note that all services are for research use only. Not intended for any clinical use.

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