Gene: THAP12
Official Full Name: THAP domain containing 12provided by HGNC
Gene Summary: Predicted to enable several functions, including DNA binding activity; metal ion binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of cell population proliferation and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00086 | THAP12 Knockout cell line (A549) | Human | THAP12 | 1:3~1:4 | Negative | Online Inquiry |
KO35909 | THAP12 Knockout cell line (HeLa) | Human | THAP12 | 1:3~1:6 | Negative | Online Inquiry |
KO35910 | THAP12 Knockout cell line (HCT 116) | Human | THAP12 | 1:2~1:4 | Negative | Online Inquiry |
KO35911 | THAP12 Knockout cell line (HEK293) | Human | THAP12 | 1:3~1:6 | Negative | Online Inquiry |
THAP12 Gene Knockout Cell Lines are specifically engineered cellular models designed for advanced research in gene function and disease mechanisms. Generating these cell lines involves targeted disruption of the THAP12 gene, which encodes a DNA-binding protein that plays pivotal roles in transcription regulation and cellular growth. The knockout technique primarily employs CRISPR-Cas9 technology, allowing for precise edits in the genome, thus rendering these cells devoid of THAP12 functionality.
The key function of THAP12 Gene Knockout Cell Lines lies in their ability to elucidate the biological roles of the THAP12 protein and its associated pathways. In research settings, these cell lines enable scientists to explore gene expression profiles, cellular signaling processes, and the molecular basis of pathologies linked to THAP12 dysfunction, such as certain cancers or developmental disorders. Furthermore, by utilizing these knockout models, researchers can investigate the effects of THAP12 absence on cellular behaviors, including proliferation, differentiation, and apoptosis, providing a comprehensive understanding of its role within various biological contexts.
The scientific importance of these cell lines extends to their utility in validating therapeutic targets, screening for drug efficacy, and studying gene therapy approaches. Unlike conventional cell lines that may exhibit variability in gene expression, the THAP12 Gene Knockout Cell Lines provide a stable and reproducible research platform, minimizing biological variability and enhancing experimental consistency.
What distinguishes our THAP12 Gene Knockout Cell Lines from alternatives is their rigorous validation and characterization, ensuring that each line exhibits complete gene knockout and consistent performance across various experiments. Researchers benefit from our comprehensive support, including detailed protocols and expert scientific guidance.
In providing these innovative tools, our company showcases its expertise in genetic engineering, molecular biology, and cell line development, solidifying our commitment to advancing research in genetics and therapeutic interventions. The THAP12 Gene Knockout Cell Lines are an invaluable resource for researchers and clinicians striving to uncover new insights into gene function and disease progression.
Please note that all services are for research use only. Not intended for any clinical use.
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