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TEF Knockout Cell Lines

Gene: TEF

Official Full Name: TEF transcription factor, PAR bZIP family memberprovided by HGNC

Gene Summary: This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35059 TEF Knockout cell line (HeLa) Human TEF 1:3~1:6 Negative Online Inquiry
KO35060 TEF Knockout cell line (HCT 116) Human TEF 1:2~1:4 Negative Online Inquiry
KO35061 TEF Knockout cell line (HEK293) Human TEF 1:3~1:6 Negative Online Inquiry
KO35062 TEF Knockout cell line (A549) Human TEF 1:3~1:4 Negative Online Inquiry

Background

TEF Gene Knockout Cell Lines are a cutting-edge biotechnology tool designed to facilitate the functional study of the TEF (Transcription Enhancer Factor) gene and its role in various biological processes. Generated through advanced CRISPR-Cas9 gene-editing technology, these cell lines are characterized by the precise disruption of the TEF gene, thereby allowing researchers to investigate the gene's functions and its implications in cellular signaling, gene expression, and developmental biology.

The mechanisms underlying the utility of TEF Gene Knockout Cell Lines stem from their ability to mimic loss-of-function mutations seen in natural biological systems. By observing the phenotypic and genotypic changes that occur in these knockout models, scientists can elucidate the pathways that TEF influences and how its dysregulation might contribute to disease states, such as cancer or metabolic disorders. This makes them invaluable in both translational research and basic biological studies.

In clinical and research settings, TEF Gene Knockout Cell Lines hold significant scientific importance, as they enable the exploration of therapeutic targets and biomarker identification. For instance, by understanding the TEF gene's role in tumorigenesis, researchers can develop targeted interventions that may lead to improved clinical outcomes.

What sets TEF Gene Knockout Cell Lines apart from alternative products is their high specificity and efficiency, derived from the precise nature of CRISPR-Cas9 technology. When compared to conventional gene silencing methods such as RNA interference, these knockout lines provide permanent alteration of the gene, ensuring consistent results in long-term studies.

For researchers and clinicians aiming to expand the understanding of TEF's biological impact, these knockout cell lines offer a reliable and effective solution. The ability to create reproducible and precise models accelerates the pace of discovery and encourages innovative approaches to treatment.

Our company specializes in providing cutting-edge biological tools, including a comprehensive range of knockout cell lines, all backed by a commitment to quality and scientific integrity. We aim to support researchers in their quest to unravel the complexities of gene function, contributing to advancements in medicine and biotechnology.

Please note that all services are for research use only. Not intended for any clinical use.

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