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TCTN3 Knockout Cell Lines

Gene: TCTN3

Official Full Name: tectonic family member 3provided by HGNC

Gene Summary: This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28290 TCTN3 Knockout cell line (HeLa) Human TCTN3 1:3~1:6 Negative Online Inquiry
KO28291 TCTN3 Knockout cell line (HCT 116) Human TCTN3 1:2~1:4 Negative Online Inquiry
KO28292 TCTN3 Knockout cell line (HEK293) Human TCTN3 1:3~1:6 Negative Online Inquiry
KO28293 TCTN3 Knockout cell line (A549) Human TCTN3 1:3~1:4 Negative Online Inquiry

Background

TCTN3 Gene Knockout Cell Lines are genetically modified cell models designed to facilitate the study of the TCTN3 gene, which plays a crucial role in cellular signaling and development. These knockout cell lines are produced using state-of-the-art CRISPR-Cas9 technology, effectively disabling the TCTN3 gene to elucidate its function and association with various biological processes. By removing the gene's expression, researchers can observe the resulting phenotypic changes, providing insights into the gene's contributions to cellular pathways.

The primary function of TCTN3 involves its participation in the regulation of the Hedgehog signaling pathway, which is vital for embryonic development and tissue regeneration. Disruption of TCTN3 is linked to various pathologies, including cancer and developmental disorders, making these cell lines pivotal for both basic and applied research. In clinical settings, understanding TCTN3's role can lead to potential therapeutic targets, aiding in the development of innovative treatments.

One significant advantage of TCTN3 Gene Knockout Cell Lines is their ability to replicate conditions that mimic specific genetic deficiencies observed in patient-derived samples. Compared to traditional methods such as RNA interference, CRISPR-based knockout provides a more precise and permanent alteration of the genome, enhancing the validity of experimental results. Moreover, our knockout lines are thoroughly characterized and validated to ensure their reliability and reproducibility in diverse experimental setups.

For researchers and clinicians, TCTN3 Gene Knockout Cell Lines offer an invaluable tool for dissecting complex biological pathways and investigating the molecular mechanisms underlying various diseases. This allows for a deeper understanding of disease progression and the potential for developing novel therapeutic strategies.

Our company specializes in producing high-quality, genetically modified cell lines with a commitment to advancing research in molecular biology and genetics. With our expertise, we provide researchers with reliable tools to further their scientific inquiries and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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