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TCTN1 Knockout Cell Lines

Gene: TCTN1

Official Full Name: tectonic family member 1provided by HGNC

Gene Summary: This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary axoneme and the basal body. A mutation in this gene was found in a family with Joubert syndrome-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13502 TCTN1 Knockout cell line (HeLa) Human TCTN1 1:3~1:6 Negative Online Inquiry
KO13503 TCTN1 Knockout cell line (HCT 116) Human TCTN1 1:2~1:4 Negative Online Inquiry
KO13504 TCTN1 Knockout cell line (HEK293) Human TCTN1 1:3~1:6 Negative Online Inquiry
KO13505 TCTN1 Knockout cell line (A549) Human TCTN1 1:3~1:4 Negative Online Inquiry

Background

TCTN1 Gene Knockout Cell Lines consist of genetically modified cells in which the Tectonic 1 (TCTN1) gene has been effectively disrupted, thereby enabling researchers to study the gene’s biological functions and its role in various cellular processes. This innovative tool is pivotal in elucidating the molecular mechanisms underlying TCTN1-related pathways, notably those associated with cilia formation, cellular signaling, and developmental processes.

The key function of these knockout cell lines involves the absence of TCTN1, which can lead to observable phenotypic changes and variations in cellular behavior. Researchers utilize techniques such as CRISPR-Cas9 to achieve precise gene editing, allowing for in-depth analyses of the implications of TCTN1 loss in vivo and in vitro. By understanding how the lack of this gene influences cellular dynamics, researchers can gain insights into disease mechanisms especially in conditions like ciliopathies, where TCTN1 plays a significant role.

From a scientific perspective, TCTN1 Gene Knockout Cell Lines are invaluable in both research and clinical applications. They serve as essential models for drug discovery, genetic studies, and developmental biology, facilitating the identification of potential therapeutic targets for conditions linked to ciliary dysfunction. Unlike traditional cell lines that may express TCTN1, these knockout models provide a purely controlled environment to assess the specific impacts of TCTN1 deletion, thereby enhancing the reliability of experimental results.

One of the standout advantages of our TCTN1 Gene Knockout Cell Lines lies in their ease of use along with robust characterization data that supports reproducibility in experiments. They are validated for consistent performance across multiple research settings, distinguishing them from alternative models available in the market.

For researchers and clinicians aiming to deepen their understanding of TCTN1 and its associated biological pathways, these knockout cell lines represent an essential resource that not only contributes to fundamental science but also bridges the gap towards potential therapeutic advancements. With our extensive expertise in genome editing technologies, we are committed to providing high-quality products that facilitate groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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