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TCOF1 Knockout Cell Lines

Gene: TCOF1

Official Full Name: treacle ribosome biogenesis factor 1provided by HGNC

Gene Summary: This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35086 TCOF1 Knockout cell line (HeLa) Human TCOF1 1:3~1:6 Negative Online Inquiry
KO35087 TCOF1 Knockout cell line (HCT 116) Human TCOF1 1:2~1:4 Negative Online Inquiry
KO35088 TCOF1 Knockout cell line (HEK293) Human TCOF1 1:3~1:6 Negative Online Inquiry
KO35089 TCOF1 Knockout cell line (A549) Human TCOF1 1:3~1:4 Negative Online Inquiry

Background

TCOF1 Gene Knockout Cell Lines are specialized cell lines engineered for the targeted disruption of the TCOF1 gene, which is crucial in the development of the craniofacial structure. This biologically-relevant product leverages advanced gene-editing technologies, such as CRISPR-Cas9, to create precise mutations that allow researchers to study the functional outcomes of TCOF1 loss and its implications in disorders like Treacher Collins syndrome.

The key functions of TCOF1 Gene Knockout Cell Lines include enabling the examination of gene function, protein interactions, and the cellular pathways involved in craniofacial development. Researchers can observe the resulting phenotypic changes resulting from TCOF1 disruption, offering insights into the molecular mechanisms underlying various developmental anomalies. This product serves as an indispensable tool in both basic and applied biological research, allowing for the exploration of gene regulation and signaling pathways in developmental biology.

Scientifically, these cell lines hold significance as they provide models that can be used to study craniofacial morphogenesis, thereby addressing essential questions in genetics and developmental biology. Increased understanding of TCOF1-related processes also offers potential translational applications, leading to the development of new therapeutic strategies for individuals affected by craniofacial syndromes.

The unique selling points of TCOF1 Gene Knockout Cell Lines include their high efficiency and specificity in gene editing, reduced off-target effects, and extensive characterization data supporting their use. Unlike other models, these cell lines are designed for reproducibility and scalability, allowing laboratories with varying capacities to adopt them into their research pipelines easily.

For researchers and clinicians working to decode the complexities of genetic diseases, TCOF1 Gene Knockout Cell Lines represent a valuable asset, providing not only a reliable experimental model but also a foundation for future therapeutic developments. Our company prides itself on its commitment to advancing genetic research through innovative and accessible biological products, making a meaningful impact on the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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