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TCAF1 Knockout Cell Lines

Gene: TCAF1

Official Full Name: TRPM8 channel associated factor 1provided by HGNC

Gene Summary: Enables transmembrane transporter binding activity. Involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32824 TCAF1 Knockout cell line (HeLa) Human TCAF1 1:3~1:6 Negative Online Inquiry
KO32825 TCAF1 Knockout cell line (HCT 116) Human TCAF1 1:2~1:4 Negative Online Inquiry
KO32826 TCAF1 Knockout cell line (HEK293) Human TCAF1 1:3~1:6 Negative Online Inquiry
KO32827 TCAF1 Knockout cell line (A549) Human TCAF1 1:3~1:4 Negative Online Inquiry

Background

TCAF1 Gene Knockout Cell Lines are genetically engineered cell lines designed to provide researchers with a tool to study the specific functional role of the TCAF1 gene in cellular processes. TCAF1, or Transcriptional Cofactor Associated Factor 1, is implicated in various regulatory mechanisms influencing transcription, cell proliferation, and apoptosis. By completely disrupting the TCAF1 gene, these knockout cell lines allow for the direct examination of resulting phenotypic and biochemical changes, providing insight into the gene's contribution to disease states, especially within cancer biology and cellular signaling pathways.

The key function of TCAF1 Gene Knockout Cell Lines centers on their capacity to delineate the gene's role in regulating transcription factors and their downstream targets. Researchers can utilize these cell lines to conduct loss-of-function studies, elucidating pathways associated with cell survival and growth. Mechanistically, the absence of TCAF1 can reveal altered responses to stressors and cellular cues, thus informing on potential therapeutic targets.

From a scientific standpoint, these knockout models are invaluable in both research and clinical applications. In on-going studies of cancer, for example, understanding the function of TCAF1 can assist in the identification of new biomarkers and therapeutic strategies. Additionally, the ability to investigate cellular responses in a controlled environment facilitates enhanced insights into gene therapy techniques and personalized medicine approaches.

What sets TCAF1 Gene Knockout Cell Lines apart from alternative models is their specificity—allowing for precise and reproducible investigations into gene function, compared to non-targeted gene silencing methods. As a product, they can substantially reduce the time required for experimental validation and yield more reliable data, thereby aiding researchers in making informed decisions in their experimental designs.

Ultimately, TCAF1 Gene Knockout Cell Lines represent a significant advancement in the toolkit available to researchers and clinicians aiming to unravel complex biological questions. Our company, known for its commitment to high-quality genetic tools and expertise in molecular biology, offers these cell lines to empower scientific discovery and innovation in gene function research.

Please note that all services are for research use only. Not intended for any clinical use.

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