Gene: TBL1X
Official Full Name: transducin beta like 1 X-linkedprovided by HGNC
Gene Summary: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20173 | TBL1X Knockout cell line (HeLa) | Human | TBL1X | 1:3~1:6 | Negative | Online Inquiry |
KO20174 | TBL1X Knockout cell line (HCT 116) | Human | TBL1X | 1:2~1:4 | Negative | Online Inquiry |
KO20175 | TBL1X Knockout cell line (HEK293) | Human | TBL1X | 1:3~1:6 | Negative | Online Inquiry |
KO20176 | TBL1X Knockout cell line (A549) | Human | TBL1X | 1:3~1:4 | Negative | Online Inquiry |
TBL1X Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the TBL1X gene, which plays a crucial role in various signaling pathways, particularly in relation to transcriptional regulation and cellular differentiation. By using CRISPR/Cas9 technology or similar genome editing techniques, these cell lines provide researchers with precise tools for studying the functional implications of TBL1X deficiency both in vitro and in vivo.
The primary function of TBL1X Gene Knockout Cell Lines is to facilitate the investigation of TBL1X's involvement in key biological processes, including cancer progression, neurodegenerative diseases, and immune response modulation. Researchers can utilize these knockout models to dissect the pathways influenced by TBL1X, illuminating its role in disease mechanisms and potentially facilitating the development of targeted therapies. The knockout approach allows for the direct observation of phenotypic changes, providing insights into how the loss of this gene alters cellular behavior.
In a research context, the importance of TBL1X Gene Knockout Cell Lines is underscored by their applicability to high-throughput screening and drug discovery initiatives, enabling scientists to evaluate the efficacy of novel compounds in a controlled environment that accurately reflects the absence of TBL1X. Furthermore, these cell lines can be integrated with various omics technologies to enhance our understanding of gene-gene and gene-environment interactions, making them indispensable for modern biological research.
What sets TBL1X Gene Knockout Cell Lines apart from conventional cell models is their specificity and reproducibility. Traditional knockout models often exhibit off-target effects or incomplete knockouts, whereas our meticulously developed lines ensure a homogeneous absence of TBL1X, thereby providing a more reliable platform for experimentation. Additionally, these cell lines come with a comprehensive characterization report that highlights their genetic stability and phenotypic consistency.
For researchers and clinicians, the value of TBL1X Gene Knockout Cell Lines lies in their ability to foster advancements in therapeutic strategies and biomarker identification, ultimately enhancing patient outcomes through innovative approaches. Our company specializes in high-quality biological products, and we pride ourselves on delivering cutting-edge tools that meet the rigorous demands of the scientific community. By choosing TBL1X Gene Knockout Cell Lines, users gain access to robust models that promise to elevate their research endeavors and therapeutic discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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