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TAPBPL Knockout Cell Lines

Gene: TAPBPL

Official Full Name: TAP binding protein likeprovided by HGNC

Gene Summary: Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13586 TAPBPL Knockout cell line (HeLa) Human TAPBPL 1:3~1:6 Negative Online Inquiry
KO13587 TAPBPL Knockout cell line (A549) Human TAPBPL 1:3~1:4 Negative Online Inquiry

Background

TAPBPL Gene Knockout Cell Lines are specifically engineered cellular models that have had the TAPBPL gene disrupted to study its role in various biological processes and disease mechanisms. TAPBPL, or TAP binding protein-like, plays a critical role in the immune response, particularly in the regulation of antigen presentation. By creating cell lines devoid of this gene, researchers can investigate the downstream effects on immune signaling, protein trafficking, and cellular stress responses.

The primary mechanism of TAPBPL involves its interaction with major histocompatibility complex (MHC) molecules, influencing their stability and transport to the cell surface. By utilizing TAPBPL Gene Knockout Cell Lines, scientists can elucidate pathways involved in immune evasion by pathogens or tumors, thus providing insights into potential therapeutic targets. The ability to manipulate these cells offers valuable avenues for research in immunology, cancer biology, and therapeutic development.

The scientific significance of these cell lines is underscored by their versatility in both basic research and clinical settings. They allow for the screening of drug candidates aimed at enhancing immune responses and offer a platform for understanding genetic contributions to diseases linked to immune dysfunction. Compared to traditional cell lines, TAPBPL knockout models provide a more relevant framework for studying specific gene functions and interactions in a controlled manner.

One of the unique advantages of TAPBPL Gene Knockout Cell Lines is their ease of use and reproducibility, providing researchers with reliable data that others may not obtain through conventional experimental models. Additionally, their specificity enhances the robustness of experimental outcomes, assisting researchers in making informed decisions regarding subsequent studies.

Ultimately, TAPBPL Gene Knockout Cell Lines represent a crucial tool for researchers and clinicians alike, enabling them to investigate complex biological mechanisms with greater precision. Our company’s commitment to advancing scientific innovation ensures that we provide high-quality biological products and cell lines that are meticulously developed to support cutting-edge research and applications in gene function analysis and therapeutic discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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