Gene: TANK
Official Full Name: TRAF family member associated NFKB activatorprovided by HGNC
Gene Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32369 | TANK Knockout cell line (HeLa) | Human | TANK | 1:3~1:6 | Negative | Online Inquiry |
KO32370 | TANK Knockout cell line (HCT 116) | Human | TANK | 1:2~1:4 | Negative | Online Inquiry |
KO32371 | TANK Knockout cell line (HEK293) | Human | TANK | 1:3~1:6 | Negative | Online Inquiry |
KO32372 | TANK Knockout cell line (A549) | Human | TANK | 1:3~1:4 | Negative | Online Inquiry |
TANK Gene Knockout Cell Lines are advanced cellular models engineered to specifically target and disrupt the TANK (TRAF family member-associated NFKB activator) gene, a critical player in NF-κB signaling pathways. These knockout models allow researchers to investigate the biological roles and molecular mechanisms governed by TANK in various cellular processes, including immune response, inflammatory pathways, and potentially viral infection dynamics. By systematically knocking out the TANK gene, these cell lines present a unique opportunity to study the downstream effects on gene expression and cellular activities critical for both basic research and therapeutic developments.
The cell lines function through CRISPR-Cas9 technology or similar gene-editing methodologies, ensuring a precise and stable disruption of the TANK gene. This results in significant alterations in cellular behavior and signaling, providing critical insights into pathophysiological conditions such as autoimmune diseases, cancers, and chronic infections, where TANK's functionality may be compromised or altered.
The scientific importance of TANK Gene Knockout Cell Lines is underscored by their utility in a myriad of applications, including drug discovery, therapeutic target validation, and genetic pathway analysis. Researchers can effectively model the absence of TANK in a controlled environment, allowing for a results-driven investigation into how its knockout influences disease progression and treatment responses.
Compared to traditional cell lines, which may bear natural variability and questionable relevance in specific gene functions, TANK Gene Knockout Cell Lines provide a homogenous, reproducible platform that minimizes background noise and maximizes experimental reliability. This targeted approach not only enhances the accuracy of experimental data but also accelerates the pace of discovery in both academic and commercial research settings.
For researchers and clinicians aiming to unlock the intricacies of immune regulation and inflammatory responses, TANK Gene Knockout Cell Lines offer an invaluable resource. By understanding the nuances of TANK's biological activity, users can pave the way for novel therapeutic strategies and treatments.
Our company prides itself on a commitment to cutting-edge biological research and a portfolio of meticulously curated products. With a focus on quality and scientific integrity, we equip researchers and clinicians with the tools they need to advance their studies and bridge the gap between laboratory findings and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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