Gene: TAMALIN
Official Full Name: trafficking regulator and scaffold protein tamalinprovided by HGNC
Gene Summary: This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13592 | TAMALIN Knockout cell line (HEK293) | Human | TAMALIN | 1:3~1:6 | Negative | Online Inquiry |
TAMALIN Gene Knockout Cell Lines are pre-engineered cellular models designed to enable targeted gene disruption through advanced CRISPR technology. These cell lines have been meticulously generated to facilitate the study of gene function and cellular pathways by providing a readily available tool for gene manipulation and analysis. TAMALIN cell lines are created to knockout specific genes of interest, allowing researchers to observe phenotypic alterations, compensatory mechanisms, and signaling pathway interactions that may result from gene loss.
The key mechanism driving TAMALIN Gene Knockout Cell Lines is the precise editing of genomic sequences via CRISPR-Cas9 technology. By employing guide RNAs (gRNAs) that match the target sequences, the Cas9 nuclease creates double-strand breaks, which are subsequently repaired through error-prone repair pathways, leading to insertions or deletions that disrupt gene function. This targeted approach allows for the creation of stable knockout variants, which are essential for dissecting the roles of individual genes within various biological contexts.
In research settings, these cell lines are invaluable for elucidating gene function, investigating disease mechanisms, and testing therapeutic strategies — particularly in the fields of oncology, genetics, and drug discovery. Clinicians can also leverage these models to better understand genetic disorders and develop more effective treatments.
What sets TAMALIN Gene Knockout Cell Lines apart from other gene disruption tools is their unparalleled specificity, ease of use, and reproducibility. Unlike traditional methods, such as siRNA or other transient transfection techniques, these knockout lines provide stable alterations in gene expression, ensuring consistent results over time. Moreover, our offerings are backed by rigorous validation processes, ensuring that each cell line performs reliably in various applications.
For researchers and clinicians looking to drive their studies forward, TAMALIN Gene Knockout Cell Lines provide an essential resource that can transform understanding of gene function and accelerate product development. With a strong commitment to innovation, our company has developed a diverse array of biological products, underscored by our expertise in gene editing technologies, ensuring that our customers are equipped with the highest quality tools to advance their research and clinical endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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