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TAF5L Knockout Cell Lines

Gene: TAF5L

Official Full Name: TATA-box binding protein associated factor 5 likeprovided by HGNC

Gene Summary: The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27843 TAF5L Knockout cell line (HeLa) Human TAF5L 1:3~1:6 Negative Online Inquiry
KO27844 TAF5L Knockout cell line (HCT 116) Human TAF5L 1:2~1:4 Negative Online Inquiry
KO27845 TAF5L Knockout cell line (HEK293) Human TAF5L 1:3~1:6 Negative Online Inquiry
KO27846 TAF5L Knockout cell line (A549) Human TAF5L 1:3~1:4 Negative Online Inquiry

Background

TAF5L Gene Knockout Cell Lines are sophisticated experimental tools designed for the investigation of TAF5L (TATA-box binding protein associated factor 5-like) gene function. These cell lines are genetically engineered to inactivate the TAF5L gene, enabling researchers to study the consequences of its absence on cellular processes. The knockout methodology leverages advanced CRISPR-Cas9 technology, which ensures precise and efficient gene editing, resulting in a robust and consistent model for functional analysis.

The primary function of TAF5L has been linked to transcriptional regulation and cellular differentiation, particularly within specific tissues such as the central nervous system. By utilizing the TAF5L Gene Knockout Cell Lines, researchers can elucidate the downstream signaling pathways and gene expression profiles activated or repressed in the absence of TAF5L, thereby gaining insights into its role in various biological phenomena, including neurogenesis and tumorigenesis. Such investigations have significant implications in both fundamental biology and clinical research, potentially offering new avenues for therapeutic interventions in disorders where TAF5L is implicated.

One of the standout advantages of TAF5L Gene Knockout Cell Lines compared to conventional methods is the specificity and reproducibility of the gene editing process, which reduces off-target effects commonly associated with earlier genetic manipulation techniques. Additionally, these cell lines facilitate high-throughput screening and functional assays, making them invaluable resources for both basic science and translational research.

For researchers and clinicians, the ability to precisely control gene expression through knockout strategies provides a powerful platform for investigating disease mechanisms and testing novel therapeutic approaches. TAF5L Gene Knockout Cell Lines are a critical addition to the toolbox of modern molecular biology.

Our company is dedicated to advancing biological research through innovative genetic tools, and our expertise in gene editing technologies ensures that we provide high-quality, reliable products to support your scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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