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TAB1 Knockout Cell Lines

Gene: TAB1

Official Full Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 1provided by HGNC

Gene Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10991 TAB1 Knockout cell line (HeLa) Human TAB1 1:3~1:6 Negative Online Inquiry
KO10992 TAB1 Knockout cell line (HCT 116) Human TAB1 1:2~1:4 Negative Online Inquiry
KO10993 TAB1 Knockout cell line (HEK293) Human TAB1 1:3~1:6 Negative Online Inquiry
KO10994 TAB1 Knockout cell line (A549) Human TAB1 1:3~1:4 Negative Online Inquiry

Background

TAB1 Gene Knockout Cell Lines are genetically engineered cell lines where the TAB1 gene has been selectively inactivated. This innovative product allows researchers to study the specific functional roles and biological pathways associated with TAB1, which is known to play a crucial role in various cellular processes, including immunity and inflammation. By providing a clear view of the gene's effects void of its native activity, these knockout cell lines serve as an indispensable tool for dissecting the molecular mechanisms underlying TAB1's involvement in health and disease.

Mechanistically, TAB1 is implicated in the activation of key signaling pathways, particularly those involved in the NF-kB and MAPK cascades. By using these knockout cell lines in experimental settings, researchers can elucidate the consequences of TAB1 loss on cellular behavior, including proliferation, differentiation, and response to external stimuli. Such insights are critical for understanding the pathological mechanisms of diseases, including cancer and autoimmune disorders.

The scientific importance of TAB1 Gene Knockout Cell Lines extends into both research and clinical applications. These cell lines are invaluable for drug discovery, allowing for the identification of potential therapeutic targets and the evaluation of drug efficacy in the absence of TAB1 activity. Furthermore, they can facilitate biomarker discovery and enhance understanding of disease progression in conditions where TAB1 is dysregulated.

One of the standout advantages of our TAB1 Gene Knockout Cell Lines is the precision of the gene editing employed, which ensures complete and reproducible knockout of the gene. This reliability is crucial when establishing control parameters in experimental designs, making these cell lines superior to traditional models that may not fully recapitulate the gene's loss. Additionally, the availability of these knockout lines provides a more ethical and efficient approach to in vitro study compared to traditional genetic manipulation techniques.

For researchers and clinicians seeking to innovate and advance their work in genomics and cell biology, TAB1 Gene Knockout Cell Lines offer an unparalleled resource that can drive significant findings. They represent a critical leap in understanding the complex biology surrounding TAB1, and thus open avenues for novel interventions in disease management.

We take pride in our commitment to excellence and scientific innovation, consistently providing high-quality biological products backed by robust research and development. Our expertise in developing cutting-edge cell lines like the TAB1 Gene Knockout Cell Lines reflects our dedication to advancing scientific progress and improving research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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