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SYT5 Knockout Cell Lines

Gene: SYT5

Official Full Name: synaptotagmin 5provided by HGNC

Gene Summary: Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35153 SYT5 Knockout cell line (HCT 116) Human SYT5 1:2~1:4 Negative Online Inquiry

Background

SYT5 Gene Knockout Cell Lines are meticulously developed cellular models designed to elucidate the biological role of the SYT5 gene, which encodes for synaptotagmin-5, a critical protein implicated in synaptic transmission and cellular signaling processes. By employing CRISPR-Cas9 gene-editing technology, these cell lines enable precise disruption of the SYT5 gene, allowing researchers to examine the resulting phenotypic alterations in neuronal and non-neuronal cells.

The primary function of SYT5 Gene Knockout Cell Lines lies in their ability to facilitate detailed studies on neurotransmission mechanisms and synaptic regulation. When the SYT5 gene is knocked out, researchers can observe changes in synaptic vesicle dynamics, assess the impact on calcium-dependent signaling pathways, and explore potential interactions with other synaptic proteins. This functional analysis provides invaluable insights into the molecular underpinnings of neurological disorders and synaptic dysfunction.

From a scientific perspective, these knockout cell lines hold significant importance in both research and clinical settings. They serve as powerful tools for investigating pathophysiological mechanisms associated with disorders such as autism spectrum disorders, schizophrenia, and neurodegeneration. By utilizing the SYT5 gene knockout models, researchers can develop therapeutic strategies that target synaptic malfunction, ultimately leading toward advancements in treatment options.

One of the standout advantages of SYT5 Gene Knockout Cell Lines compared to alternative models is their specificity and accuracy in mimicking natural gene deletions. Other methods for gene suppression, such as RNA interference, often yield incomplete knocking down of target genes, whereas CRISPR-Cas9 ensures permanent and precise disruptions. Additionally, these cell lines are adaptable for high-throughput screening, enabling comprehensive drug discovery and functional assays.

The value of SYT5 Gene Knockout Cell Lines lies in their ability to accelerate research and enhance understanding of complex neurological processes. For researchers and clinicians alike, possessing a reliable and effective tool for exploring synaptotagmin functions and related signaling pathways is essential in advancing scientific knowledge and developing innovative therapeutic interventions.

At [Your Company Name], we offer an extensive portfolio of high-quality biological products, underpinned by our deep expertise in molecular biology and a commitment to support groundbreaking research and clinical applications. Our SYT5 Gene Knockout Cell Lines exemplify our dedication to empowering scientists with the tools necessary to unravel the complexities of gene function and its implications in human health.

Please note that all services are for research use only. Not intended for any clinical use.

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