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SVIL Knockout Cell Lines

Gene: SVIL

Official Full Name: supervillinprovided by HGNC

Gene Summary: This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35167 SVIL Knockout cell line (HeLa) Human SVIL 1:3~1:6 Negative Online Inquiry
KO35168 SVIL Knockout cell line (HCT 116) Human SVIL 1:2~1:4 Negative Online Inquiry
KO35169 SVIL Knockout cell line (HEK293) Human SVIL 1:3~1:6 Negative Online Inquiry
KO35170 SVIL Knockout cell line (A549) Human SVIL 1:3~1:4 Negative Online Inquiry

Background

SVIL Gene Knockout Cell Lines are specially engineered cell lines designed to facilitate advanced research in gene expression, cellular function, and drug discovery by providing a model system where the SVIL gene (also known as the 'silk protein' gene) has been precisely knocked out. Knocking out the SVIL gene allows researchers to study the biological consequences of its loss, including its implications in cellular processes such as motility, adhesion, and signaling pathways, which are critical for understanding various diseases and developing therapeutic strategies.

The primary function of these knockout cell lines lies in their ability to mimic pathological conditions and allow researchers to dissect the role of the SVIL gene in vivo. By eliminating the expression of this gene, scientists can observe resultant phenotypic changes in cell behavior, thereby elucidating the molecular mechanisms underpinning various biological interactions. Additionally, these cell lines can be utilized to screen potential drugs targeting specific pathways influenced by SVIL, making them a vital tool in translational research.

From a scientific perspective, the SVIL Gene Knockout Cell Lines hold immense potential not only for basic research but also for clinical applications, including cancer biology, regenerative medicine, and congenital disorders. They represent a critical resource for developing targeted therapeutics that can specifically modify pathways associated with the SVIL gene.

One of the key advantages of our SVIL Gene Knockout Cell Lines is the precision with which they have been created. Unlike traditional methods that can produce off-target effects, our knockout lines utilize cutting-edge CRISPR technology to ensure specificity and reliability, enhancing experimental reproducibility. Furthermore, they are validated for consistent performance across multiple studies, setting them apart from alternative models that may suffer from variability.

For researchers and clinicians, the ability to use these specialized cell lines means gaining deeper insights into gene function and disease mechanisms, ultimately leading to more effective treatment strategies. Our committed team at [Your Company Name], with extensive expertise in cellular biology and genomic technologies, ensures that every product we offer is backed by rigorous validation and support, providing our users with unmatched confidence in their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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