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SUN2 Knockout Cell Lines

Gene: SUN2

Official Full Name: Sad1 and UNC84 domain containing 2provided by HGNC

Gene Summary: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28844 SUN2 Knockout cell line (HeLa) Human SUN2 1:3~1:6 Negative Online Inquiry
KO28845 SUN2 Knockout cell line (HCT 116) Human SUN2 1:2~1:4 Negative Online Inquiry
KO28846 SUN2 Knockout cell line (HEK293) Human SUN2 1:3~1:6 Negative Online Inquiry
KO28847 SUN2 Knockout cell line (A549) Human SUN2 1:3~1:4 Negative Online Inquiry

Background

SUN2 Gene Knockout Cell Lines are specifically engineered cellular models designed to elucidate the functional role of the SUN2 gene in various biological processes. Utilizing CRISPR-Cas9 genome editing technology, these cell lines enable precise excision of the SUN2 gene, which encodes a protein known to be pivotal in nuclear transport, cytoskeletal organization, and cellular signaling pathways. By creating a knockout of this gene, researchers can gain invaluable insights into the consequences of its absence on cellular activities and disease mechanisms.

The primary function of the SUN2 gene product involves its participation in forming nuclear-envelope connections to the cytoskeleton, ensuring proper cellular architecture and integrity. SUN2's pivotal role in mechanotransduction and gene expression regulation further underscores the significance of these knockout cell lines, making them indispensable for studying developmental biology, cancer research, and genetic disorders.

In the realm of scientific research or clinical applications, SUN2 Gene Knockout Cell Lines offer a robust platform for drug screening, functional assays, and gene-expression studies, enabling researchers to develop targeted therapies and elucidate molecular pathways implicated in various diseases. Compared to traditional methods which might be time-consuming and less specific, these knockout models allow for enhanced efficiency in experimental design and data interpretation.

As a result, the SUN2 Gene Knockout Cell Lines stand out due to their high specificity, reproducibility, and efficiency in elucidating gene-function relationships, making them a preferred choice for researchers focused on molecular biology and genetics. The elimination of the SUN2 gene provides a unique opportunity to decipher its overall impact on cellular functions, which can be critical for advancing therapeutic applications.

Our company has established a reputation for excellence in producing high-quality genetic models and cell lines, backed by a team of experienced professionals dedicated to supporting the scientific community with innovative biological solutions. This product is a testament to our commitment to enhancing research capabilities and fostering scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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