Gene: SUMF2
Official Full Name: sulfatase modifying factor 2provided by HGNC
Gene Summary: The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28700 | SUMF2 Knockout cell line (HeLa) | Human | SUMF2 | 1:3~1:6 | Negative | Online Inquiry |
KO28701 | SUMF2 Knockout cell line (HCT 116) | Human | SUMF2 | 1:2~1:4 | Negative | Online Inquiry |
KO28702 | SUMF2 Knockout cell line (HEK293) | Human | SUMF2 | 1:3~1:6 | Negative | Online Inquiry |
KO28703 | SUMF2 Knockout cell line (A549) | Human | SUMF2 | 1:3~1:4 | Negative | Online Inquiry |
SUMF2 Gene Knockout Cell Lines are specifically engineered cellular models that have undergone targeted gene disruption to eliminate the expression of the SUMF2 gene. SUMF2 encodes a sulfation factor that plays a critical role in the post-translational modification of proteins, influencing various physiological processes. The knockout of this gene serves as a powerful tool for studying its functional contributions to cellular processes, particularly in the context of sulfation pathways that are vital for hormone regulation, cell communication, and extracellular matrix remodeling.
The primary function of SUMF2 Gene Knockout Cell Lines resides in their ability to provide researchers with a clean genetic background for elucidating the biological roles and mechanisms of SUMF2 in cellular processes. By observing the phenotypic and functional changes in these cells compared to wild-type strains, scientists can gain insights into the gene's involvement in specific diseases, developmental stages, or cellular responses to various stimuli.
The scientific importance of these cell lines extends to both basic research and applied clinical settings. In research, they enable detailed investigations into the pathology of conditions such as cancer, metabolic disorders, and cardiovascular diseases, where SUMF2 has been implicated. Clinically, these knockouts can aid in identifying potential therapeutic targets, contributing to drug development processes or personalized medicine approaches.
One of the principal advantages of our SUMF2 Gene Knockout Cell Lines is their high specificity and reproducibility compared to traditional methods of gene disruption, such as chemical mutagenesis or transfection of siRNA. Our knockout models have been validated for consistent gene targeting and exhibit stable genomic integration, which ensures that researchers can rely on them for long-term experiments without the complications of variable expression levels.
For researchers, clinicians, and biopharmaceutical companies, the value of these cell lines lies in their ability to accelerate the discovery of novel therapeutic targets and enhance our understanding of disease mechanisms. By using our SUMF2 Gene Knockout Cell Lines, scientists are equipped with powerful tools that facilitate innovative research and contribute to advancements in health care.
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Please note that all services are for research use only. Not intended for any clinical use.
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