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SUMF1 Knockout Cell Lines

Gene: SUMF1

Official Full Name: sulfatase modifying factor 1provided by HGNC

Gene Summary: This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13642 SUMF1 Knockout cell line (HeLa) Human SUMF1 1:3~1:6 Negative Online Inquiry
KO13643 SUMF1 Knockout cell line (HCT 116) Human SUMF1 1:2~1:4 Negative Online Inquiry
KO13644 SUMF1 Knockout cell line (HEK293) Human SUMF1 1:3~1:6 Negative Online Inquiry
KO13645 SUMF1 Knockout cell line (A549) Human SUMF1 1:3~1:4 Negative Online Inquiry

Background

SUMF1 Gene Knockout Cell Lines are specialized cellular models developed to facilitate the comprehensive study of the SUMF1 gene, which encodes the enzyme sulfatase modifying factor 1. This enzyme is critical for the post-translational modification of sulfatases, which are involved in various biological processes, including cellular signaling and metabolism. By producing SUMF1 gene knockout cell lines, researchers can explore the effects of SUMF1 loss on cellular function and identify downstream pathways impacted by this genetic alteration.

Key functions of these knockout cell lines include the ability to investigate the pathogenic mechanisms behind sulfatase-related disorders and the modulation of various metabolic pathways. The absence of SUMF1 in these cell lines allows scientists to assess the role of unmodified sulfatases in disease contexts, offering insights into potential therapeutic targets and mechanisms underlying conditions such as neurological disorders, cancer, and other metabolic diseases.

The scientific importance of SUMF1 gene knockout cell lines is profound, particularly in translational research and drug discovery. Their application in both research and clinical settings enhances understanding of genetic diseases and provides a platform for screening potential sulfatase-targeting therapeutics. These knockout models are indispensable tools for understanding complex biological systems and advancing the field of genetics.

What sets our SUMF1 gene knockout cell lines apart from alternatives is their robust characterization and high reproducibility, ensuring that researchers obtain reliable and meaningful data. Our cell lines have been meticulously validated to ensure a complete understanding of the SUMF1 function, which minimizes experimental variability and enhances the overall quality of research.

For researchers and clinicians striving to advance their understanding of sulfatase biology and related disorders, our SUMF1 gene knockout cell lines provide a valuable resource. By choosing our product, users benefit from our commitment to quality and innovation, backed by extensive expertise in developing specialized biological products. With our established track record in cellular model systems, we are dedicated to supporting the scientific community in achieving their research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

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