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SULT1E1 Knockout Cell Lines

Gene: SULT1E1

Official Full Name: sulfotransferase family 1E member 1provided by HGNC

Gene Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35209 SULT1E1 Knockout cell line (HeLa) Human SULT1E1 1:3~1:6 Negative Online Inquiry

Background

SULT1E1 Gene Knockout Cell Lines are genetically modified cellular models specifically designed to facilitate in-depth studies of the SULT1E1 gene and its associated biological functions. SULT1E1 encodes a member of the sulfotransferase family, which plays a critical role in the sulfonation of various endogenous and exogenous compounds, influencing their bioactivity, metabolism, and disposal. By knocking out the SULT1E1 gene, these cell lines provide researchers with a powerful tool to investigate the gene's relevance in drug metabolism, hormonal regulation, and other physiological processes.

The primary function of these knockout cell lines is to elucidate the role of SULT1E1 in metabolic pathways by enabling comparative analyses with wild-type cells. This is crucial for understanding how the absence of the gene affects cellular responses to drugs, environmental toxins, and hormonal signals. Researchers can utilize these cell lines in high-throughput screening assays, toxicological assessments, or pharmacokinetic studies, providing essential insights into the safety and efficacy of therapeutic agents.

Scientifically, the SULT1E1 Gene Knockout Cell Lines are invaluable for both basic and applied research. They allow for the exploration of genetic factors that may contribute to variable drug responses among individuals, thereby supporting the development of personalized medicine approaches. Furthermore, in clinical settings, these models can facilitate the identification of potential biomarkers of drug efficacy or adverse effects, ultimately guiding therapeutic decisions.

Unlike other models, these cell lines offer a precise and advantageous solution for gene function analysis. Their targeted knockouts reduce background signal from confounding pathways, ensuring that data obtained are specific to SULT1E1. This specificity enhances the robustness of experimental results, making them more reliable than non-specific inhibitors or pharmacological agents.

For researchers and clinicians, the SULT1E1 Gene Knockout Cell Lines represent a crucial advancement in the field of molecular biology, pharmacology, and toxicology. By providing a dedicated platform for comprehensive gene function analysis, they pave the way for deeper understanding and innovation in therapeutic development.

Our company specializes in the production and characterization of advanced cellular models, ensuring that users have access to top-tier products that accelerate their research and enhance the quality of their scientific outputs.

Please note that all services are for research use only. Not intended for any clinical use.

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