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STXBP5L Knockout Cell Lines

Gene: STXBP5L

Official Full Name: syntaxin binding protein 5Lprovided by HGNC

Gene Summary: The protein encoded by this gene is similar to syntaxin-binding protein 5 and contains ten N-terminal WD40 repeats, four variable region WD40 repeats, and a C-terminal R-SNARE domain. Studies of the orthologous proteins in mouse and rat have shown that the encoded protein may inhibit exocytosis in neurosecretory cells, and may negatively regulate the secretion of insulin. A missense variant in this gene is likely the cause of an infantile-onset neurodegenerative disorder diagnosed in two siblings of consanguineous parents. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33165 STXBP5L Knockout cell line (HeLa) Human STXBP5L 1:3~1:6 Negative Online Inquiry

Background

STXBP5L Gene Knockout Cell Lines are expertly developed biotechnological tools that facilitate the study of STXBP5L, a gene associated with critical cellular processes, particularly in neurotransmitter release and synaptic function. These cell lines have been precisely engineered to generate a complete loss of STXBP5L gene expression, providing researchers with a robust model to investigate its role in various physiological and pathological conditions.

The primary mechanism of action for the STXBP5L gene knockout involves the use of CRISPR-Cas9 technology, which creates targeted double-strand breaks in the DNA at specific sites within the STXBP5L sequences. This gene disruption ultimately leads to a deficiency of the STXBP5L protein, allowing researchers to explore the consequences of its absence on cellular signaling pathways, neuronal communication, and the resultant behavioral outcomes in model organisms.

The scientific importance of STXBP5L Gene Knockout Cell Lines lies in their invaluable application in research areas such as neurobiology, pharmacology, and disease modeling. By elucidating the molecular mechanisms of STXBP5L, researchers can investigate its contributions to various neurological disorders, thereby paving the way for potential therapeutic interventions. Moreover, these cell lines are essential tools for the development of high-throughput screening assays to identify novel drug candidates targeting STXBP5L-related pathways.

One of the most significant advantages of our STXBP5L Gene Knockout Cell Lines is their high precision and reproducibility compared to traditional knockout techniques. This product eliminates off-target effects commonly associated with older methodologies, ensuring that experimental results are reliable and pertinent. Additionally, these cell lines are thoroughly characterized and validated, allowing researchers to trust the integrity of their experimental outcomes.

For researchers and clinicians alike, the ability to manipulate STXBP5L expression offers transformative opportunities to investigate complex biological questions and therapeutic applications. Our commitment to providing high-quality and innovative biological products showcases our expertise in genetic engineering and cell line development. By choosing our STXBP5L Gene Knockout Cell Lines, you gain access to a cutting-edge resource that enhances your research capabilities and accelerates discoveries in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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