Gene: STRA6
Official Full Name: signaling receptor and transporter of retinol STRA6provided by HGNC
Gene Summary: The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13667 | STRA6 Knockout cell line (HeLa) | Human | STRA6 | 1:3~1:6 | Negative | Online Inquiry |
KO13668 | STRA6 Knockout cell line (A549) | Human | STRA6 | 1:3~1:4 | Negative | Online Inquiry |
STRA6 Gene Knockout Cell Lines are engineered biological research tools designed specifically to facilitate the study of the STRA6 gene, which encodes a membrane receptor critical for retinoid signaling and vitamin A transport in cells. These cell lines are generated through precise CRISPR-Cas9 gene-editing technology, effectively disabling the STRA6 gene’s function. This knockout approach allows researchers to investigate the physiological and pathological roles of retinoic acid signaling in various cellular contexts.
The primary function of STRA6 Gene Knockout Cell Lines is to serve as a model to explore the downstream effects of disrupted retinoid homeostasis, which has implications in processes ranging from cellular differentiation to immune response modulation. By eliminating the STRA6 receptor, these cell lines provide an invaluable platform for studying diseases linked to vitamin A metabolism, including certain cancers, immune deficiencies, and developmental disorders. Researchers can utilize these models to assess cellular responses to retinoids and develop targeted therapeutics.
The scientific importance of STRA6 Gene Knockout Cell Lines is underscored by their utility in advancing our understanding of retinoid biology, while also providing a means to test hypotheses regarding retinoid-related therapeutic strategies. Compared to traditional cell lines with intact STRA6 genes, these knockout lines present clearer insights into the specific contributions of retinol transport and signaling pathways, thus enhancing the specificity of experimental outcomes.
The unique selling points of STRA6 Gene Knockout Cell Lines include their genetic specificity, reproducibility, and the ability to generate results that directly correlate with in vivo conditions. These advantages make them indispensable for researchers aiming to develop innovative approaches to mitigate diseases associated with retinoid dysregulation.
In summary, STRA6 Gene Knockout Cell Lines are a vital resource for researchers and clinicians alike. They not only enable deeper explorations into the fundamental biology of retinoids but also pave the way for novel therapeutic solutions. Our company prides itself on delivering exceptional biological products, underpinned by rigorous scientific expertise and a commitment to advancing biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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