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STAC3 Knockout Cell Lines

Gene: STAC3

Official Full Name: SH3 and cysteine rich domain 3provided by HGNC

Gene Summary: The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21473 STAC3 Knockout cell line (HCT 116) Human STAC3 1:2~1:4 Negative Online Inquiry
KO21474 STAC3 Knockout cell line (HEK293) Human STAC3 1:3~1:6 Negative Online Inquiry

Background

STAC3 Gene Knockout Cell Lines are specialized cell lines genetically engineered to lack the STAC3 gene, which is implicated in calcium signaling pathways and neuronal function. The deletion of this gene allows researchers to investigate the specific roles of STAC3 in various biological processes and diseases, leading to a deeper understanding of its associated pathways and mechanisms. These knockout cell lines serve as critical tools in the study of cellular excitability and the etiology of conditions like congenital myopathies and other neuromuscular disorders.

The primary function of STAC3 Gene Knockout Cell Lines lies in their capacity to dissect the physiological impact of STAC3 absence. By comparing the knockout lines with their wild-type counterparts, researchers can elucidate changes in calcium ion concentration, cellular signaling pathways, and muscle development. This is particularly significant in drug discovery and therapeutic interventions targeting STAC3-related diseases, where understanding the gene’s function can inform more effective treatments.

In research settings, these cell lines offer significant advantages over alternatives, such as unmodified cell lines or systems with transient suppression of STAC3. Traditional methods generally do not provide a stable platform for long-term studies, whereas knockout cell lines ensure consistent results over repeated experiments. Furthermore, the specificity of STAC3 deletion reduces off-target effects typical of RNA interference techniques, providing a clear model for studying gene function.

For clinicians and researchers alike, the value of STAC3 Gene Knockout Cell Lines extends beyond basic science. They are crucial for translational research efforts that aim to develop targeted therapies and novel diagnostics. By facilitating advancements in understanding the physiological role of STAC3, these cell lines can aid in the early identification of genetic conditions and the assessment of therapeutic strategies.

Our company prides itself on its dedication to delivering high-quality, precisely engineered biological products tailored to meet the diverse needs of the scientific community. With years of experience in gene editing technologies and a commitment to advancing research, we ensure that our STAC3 Gene Knockout Cell Lines are exemplary tools for exploring critical gene functions and their implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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