Gene: SSTR5
Official Full Name: somatostatin receptor 5provided by HGNC
Gene Summary: Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07577 | SSTR5 Knockout cell line (HCT 116) | Human | SSTR5 | 1:2~1:4 | Negative | Online Inquiry |
SSTR5 Gene Knockout Cell Lines are expertly engineered cell models that have had the somatostatin receptor 5 (SSTR5) gene disrupted, providing invaluable resources for researchers studying the physiological roles of this receptor and its associated signaling pathways. SSTR5 is known to play a critical part in neuroendocrine signaling, mediating effects on cell proliferation, apoptosis, and neurotransmitter release. By employing CRISPR-Cas9 or other gene-editing technologies, these cell lines enable precise modulation of SSTR5 expression, which is essential for dissecting its functional roles in health and disease.
The primary mechanism of these knockout cell lines involves the complete disruption of the SSTR5 gene, leading to the ablation of protein function. Researchers can utilize these lines to investigate the impact of SSTR5 deficiency on various cellular processes, including hormone regulation and tumor biology. This is particularly relevant in cancer research, where SSTR5 may serve as a potential therapeutic target due to its influence on tumor growth and metastasis.
The scientific importance of SSTR5 Gene Knockout Cell Lines extends beyond basic research; they offer significant applications in pharmacology and drug discovery, allowing for the development of more targeted therapies. Their unique selling points include the reliability of results obtained from using established knockout models, the high specificity of gene editing, and the reproducibility of data, which contrasts with traditional methods that may yield inconsistent results.
For researchers and clinicians alike, the ability to study diseases through the lens of SSTR5 signaling pathways provides a deeper understanding of their mechanisms, paving the way for novel interventions. Our company prides itself on delivering high-quality biological products, with a commitment to enhancing research capabilities through innovative solutions. We ensure that our SSTR5 Gene Knockout Cell Lines are validated, extensively characterized, and come with comprehensive technical support, affirming our dedication to advancing scientific discovery in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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