Gene: SSTR1
Official Full Name: somatostatin receptor 1provided by HGNC
Gene Summary: Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07578 | SSTR1 Knockout cell line (HeLa) | Human | SSTR1 | 1:3~1:6 | Negative | Online Inquiry |
SSTR1 Gene Knockout Cell Lines are genetically modified cell lines in which the somatostatin receptor type 1 (SSTR1) gene has been systematically disrupted to study the functional implications of SSTR1 in various biological contexts. These cell lines serve as essential tools for research in cellular signaling pathways, neurobiology, and the development of therapeutics targeting the somatostatin signaling pathway, which plays a crucial role in diverse physiological processes, including hormone secretion, cell proliferation, and neurotransmission.
The primary function of these knockout cell lines is to eliminate SSTR1-mediated signaling, thereby allowing researchers to dissect the consequences of SSTR1 loss on cellular behavior and receptor interactions. By observing the differences in cellular functions, including changes in growth rates, differentiation, and response to various pharmacological agents, scientists can gain insight into the receptor's role in pathophysiological conditions, such as tumors and metabolic disorders.
The scientific significance of SSTR1 Gene Knockout Cell Lines extends to both basic and applied research. In preclinical settings, these cell lines are invaluable for drug discovery and development, especially for agents that target somatostatin receptors in the treatment of neuroendocrine tumors, acromegaly, and other disorders. By using these knockout models, researchers can effectively identify the therapeutic potential and optimize the efficacy of new compounds.
Compared to alternative models, including wild-type cell lines or other receptor knockout systems, SSTR1 Gene Knockout Cell Lines provide a specific and highly controlled environment to study the unique effects associated with the absence of this receptor. The precision of gene editing technologies ensures a high degree of specificity, reducing off-target effects that may confound experimental results, making these cell lines a more reliable choice for rigorous scientific investigation.
For researchers and clinicians focused on advancing our understanding of somatostatin receptor biology and its implications in health and disease, SSTR1 Gene Knockout Cell Lines offer a robust platform for innovative research. Our company specializes in providing high-quality biological products, backed by extensive expertise in genetic engineering and cellular biology, to support the scientific community in their pursuit of knowledge and discovery. Whether for basic research applications or translational studies, our products are designed to meet the highest standards of quality and reliability.
Please note that all services are for research use only. Not intended for any clinical use.
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