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SRPRA Knockout Cell Lines

Gene: SRPRA

Official Full Name: SRP receptor subunit alphaprovided by HGNC

Gene Summary: The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35243 SRPRA Knockout cell line (HeLa) Human SRPRA 1:3~1:6 Negative Online Inquiry
KO35244 SRPRA Knockout cell line (HCT 116) Human SRPRA 1:2~1:4 Negative Online Inquiry
KO35245 SRPRA Knockout cell line (HEK293) Human SRPRA 1:3~1:6 Negative Online Inquiry
KO35246 SRPRA Knockout cell line (A549) Human SRPRA 1:3~1:4 Negative Online Inquiry

Background

SRPRA Gene Knockout Cell Lines are specifically engineered cellular models designed to study the functional role of the SRPRA gene, which encodes for the Signal Recognition Particle Receptor Alpha (SRPRA). This gene is essential for protein translocation and post-translational modifications within the endoplasmic reticulum. By employing CRISPR/Cas9 gene editing technology, these knockout cell lines effectively eliminate the expression of the SRPRA gene, allowing researchers to investigate the implications of its absence on cellular processes and signaling pathways.

The primary function of SRPRA Gene Knockout Cell Lines is to facilitate investigations into the molecular mechanisms underlying protein synthesis and secretion. These cell lines enable scientists to model diseases associated with defects in protein transport, such as certain neurodegenerative disorders and metabolic syndromes. Researchers can leverage this innovative tool to study alterations in cellular morphology, viability, and gene expression profiles in response to cellular stressors or treatments, enhancing our understanding of complex biological networks.

The scientific importance of these cell lines extends into both research and clinical settings. They provide a platform for high-throughput screenings of potential therapeutic compounds, allowing for the identification of lead candidates that could restore normal cellular functions. Furthermore, their applications in drug development and disease modeling position them as invaluable assets in the pharmacological toolkit.

Compared to traditional cell lines that may possess residual SRPRA activity, SRPRA Gene Knockout Cell Lines present a unique advantage; they provide a clean model for the complete understanding of SRPRA-related phenomena without the confounding effects of partial gene expression. This specificity increases the reliability of experimental outcomes and accelerates the translation of research findings into clinical applications.

For researchers and clinicians focused on the molecular underpinnings of diseases and therapeutic innovation, SRPRA Gene Knockout Cell Lines are an essential tool. Their capacity to mimic specific genetic conditions ensures a robust understanding of pathology, ultimately driving advances in precision medicine.

At [Your Company Name], we specialize in offering high-quality biological research products tailored to meet the diverse needs of the scientific community. Our commitment to excellence and innovation ensures that researchers have access to state-of-the-art tools that empower their explorative endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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