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SPRED1 Knockout Cell Lines

Gene: SPRED1

Official Full Name: sprouty related EVH1 domain containing 1provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13772 SPRED1 Knockout cell line (HeLa) Human SPRED1 1:3~1:6 Negative Online Inquiry
KO13773 SPRED1 Knockout cell line (HCT 116) Human SPRED1 1:2~1:4 Negative Online Inquiry
KO13774 SPRED1 Knockout cell line (HEK293) Human SPRED1 1:3~1:6 Negative Online Inquiry
KO13775 SPRED1 Knockout cell line (A549) Human SPRED1 1:3~1:4 Negative Online Inquiry

Background

SPRED1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the function and implications of the SPRED1 gene, which plays a crucial role in cellular signal transduction pathways, especially those mediated by growth factors and receptor tyrosine kinases. These cell lines facilitate the analysis of cellular behavior in the absence of SPRED1, enabling researchers to dissect its biological roles and contributions to various physiological processes and disease conditions.

The key function of these cell lines lies in their ability to mimic the loss-of-function scenarios of the SPRED1 gene. By employing the CRISPR/Cas9 gene-editing technology, SPRED1 Gene Knockout Cell Lines exhibit a complete knockout of the SPRED1 gene, allowing researchers to observe resultant phenotypic changes, such as cellular proliferation, migration, and differentiation. This targeted approach not only clarifies the gene's function within the Ras-MAPK signaling pathway but also aids in understanding its involvement in genetic disorders and potential oncogenic processes.

The scientific importance of these cell lines extends into both basic and translational research settings. They serve as valuable tools for studying the mechanisms behind various diseases, including certain cancers where aberrant signaling pathways are common. Furthermore, these cell lines can be utilized in drug discovery, enabling researchers to evaluate the efficacy of oncological therapeutics that target pathways influenced by SPRED1.

Compared to alternatives, such as wild-type cell lines or transient expression systems, SPRED1 Gene Knockout Cell Lines provide a stable and reproducible platform that minimizes variability. The robustness of these knockout models accelerates experimentation and reduces the need for repetitive studies, saving both time and resources while maximizing experimental integrity.

For researchers and clinicians, the SPRED1 Gene Knockout Cell Lines are a crucial addition to any laboratory focused on genetic and molecular biology. They empower users to gain insights into the intricate workings of cellular signaling and open avenues for therapeutic innovation. Our company prides itself on delivering high-quality biological products, supported by extensive expertise in gene editing technologies, ensuring that you have the best tools to advance your research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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