Home / SPPL2B Knockout Cell Lines

SPPL2B Knockout Cell Lines

Gene: SPPL2B

Official Full Name: signal peptide peptidase like 2Bprovided by HGNC

Gene Summary: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13776 SPPL2B Knockout cell line (HeLa) Human SPPL2B 1:3~1:6 Negative Online Inquiry
KO13777 SPPL2B Knockout cell line (HCT 116) Human SPPL2B 1:2~1:4 Negative Online Inquiry
KO13778 SPPL2B Knockout cell line (HEK293) Human SPPL2B 1:3~1:6 Negative Online Inquiry
KO13779 SPPL2B Knockout cell line (A549) Human SPPL2B 1:3~1:4 Negative Online Inquiry

Background

SPPL2B Gene Knockout Cell Lines are specialized cellular models engineered to lack the functional SPPL2B gene, which plays a pivotal role in the regulation of cellular processes, including immune response and lipid metabolism. These knockout cell lines are generated using advanced CRISPR-Cas9 technology, ensuring precise genomic editing that abolishes SPPL2B gene expression. This results in a unique system for studying the effects of SPPL2B deficiency on various biochemical pathways and cellular functions.

The primary function of SPPL2B is its involvement in intramembrane proteolysis, influencing the processing of diverse protein substrates that are crucial for immune signaling. By utilizing these knockout cell lines, researchers can explore the downstream effects of SPPL2B inactivation, shedding light on pathways involved in immune responses and potentially identifying novel therapeutic targets for diseases characterized by aberrant immune activity.

The scientific importance of SPPL2B Gene Knockout Cell Lines extends to their applications in both basic research and clinical settings. They are invaluable tools for studying the mechanistic roles of SPPL2B in autoimmune disorders, cancer, and metabolic diseases, enabling the elucidation of disease pathways and the evaluation of new treatment strategies.

One significant advantage of our SPPL2B Gene Knockout Cell Lines is their rigorously validated and consistently reproducible nature, which sets them apart from alternative models that may not accurately reflect gene silencing or functional relevance. Additionally, our product is backed by comprehensive support, including detailed protocols and troubleshooting assistance, ensuring that researchers can seamlessly incorporate these cell lines into their experimental workflows.

For researchers and clinicians focused on understanding the complexities of immune regulation and its implications for health, SPPL2B Gene Knockout Cell Lines provide a unique opportunity to dissect and manipulate cellular environments with precision. Our commitment to quality and innovation in biological products positions us as a leader in genetic and cellular tools for biotechnology research.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.