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SPNS2 Knockout Cell Lines

Gene: SPNS2

Official Full Name: SPNS lysolipid transporter 2, sphingosine-1-phosphateprovided by HGNC

Gene Summary: The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27822 SPNS2 Knockout cell line (HeLa) Human SPNS2 1:3~1:6 Negative Online Inquiry
KO27823 SPNS2 Knockout cell line (HCT 116) Human SPNS2 1:2~1:4 Negative Online Inquiry
KO27824 SPNS2 Knockout cell line (A549) Human SPNS2 1:3~1:4 Negative Online Inquiry

Background

SPNS2 Gene Knockout Cell Lines are specialized cellular models featuring a targeted knockout of the SPNS2 gene, which encodes for the Spinster homolog 2 protein. This product is invaluable for studies related to sphingolipid metabolism, cell signaling pathways, and their implications in various physiological and pathological processes. The SPNS2 protein plays a critical role in the transport of sphingolipids, particularly in lymphocyte trafficking and migration, making these knockout cell lines essential for elucidating the cellular mechanisms underlying immune responses and inflammation.

The primary mechanism by which SPNS2 Gene Knockout Cell Lines function is through the disruption of the SPNS2 gene, leading to loss of function of the encoded protein. This enables researchers to investigate the downstream effects of SPNS2 absence on cellular behavior, signaling pathways, and metabolic processes. By providing a well-characterized system for gene editing, these cell lines facilitate the investigation into the role of SPNS2 in disease models—including autoimmune diseases, cancer, and metabolic disorders—thereby advancing our understanding of potential therapeutic interventions.

The scientific importance of these knockout cell lines is underscored by their application in both basic and translational research. As tools for screening and validation in drug development, they allow for a deeper investigation of SPNS2-related pathologies, significantly contributing to foundational research aimed at discovering novel therapeutic targets and strategies.

What sets SPNS2 Gene Knockout Cell Lines apart from other genetic models is their precise gene alteration, validated through advanced genomic technologies. They not only provide reliable consistency in experimental outcomes but also offer enhanced specificity to study the effects of SPNS2 deletion in a controlled environment, making them preferable to traditional models that may suffer from variable expression levels.

For researchers, clinicians, and industry professionals, these cell lines promise cost-effective and time-efficient pathways to significant discoveries, ultimately supporting the advancement of clinical applications. Our company's commitment to quality and innovation in biological products gives users confidence in their research endeavors, ensuring that they are equipped with the best tools for groundbreaking science.

Please note that all services are for research use only. Not intended for any clinical use.

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