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SPIRE1 Knockout Cell Lines

Gene: SPIRE1

Official Full Name: spire type actin nucleation factor 1provided by HGNC

Gene Summary: Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13784 SPIRE1 Knockout cell line (HeLa) Human SPIRE1 1:3~1:6 Negative Online Inquiry
KO13785 SPIRE1 Knockout cell line (HCT 116) Human SPIRE1 1:2~1:4 Negative Online Inquiry
KO13786 SPIRE1 Knockout cell line (HEK293) Human SPIRE1 1:3~1:6 Negative Online Inquiry
KO13787 SPIRE1 Knockout cell line (A549) Human SPIRE1 1:3~1:4 Negative Online Inquiry

Background

SPIRE1 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the SPIRE1 gene's role in cellular processes. These cell lines are created using the CRISPR-Cas9 gene-editing technology, which allows for precise removal or alteration of specific DNA sequences, thus producing a complete knockout of the SPIRE1 gene. This targeted mutation enables researchers to investigate the gene's functions, its influence on cellular signaling pathways, and its overall impact on various physiological and pathological states.

The primary function of SPIRE1 is to regulate actin dynamics, thereby influencing cell motility, morphology, and interaction with the extracellular environment. By utilizing these knockout cell lines, scientists can delineate the specific roles that SPIRE1 plays in processes such as cellular proliferation, migration, and adhesion. Moreover, the SPIRE1 knockouts provide a valuable tool for understanding its implications in diseases, including cancer metastasis and neurological disorders.

The availability of SPIRE1 Gene Knockout Cell Lines is significant for both basic and translational research. In clinical settings, this product could help illuminate the mechanisms of disease progression at a cellular level, paving the way for the development of targeted therapies. Researchers aiming to develop high-throughput screening assays or molecular studies will find these cell lines indispensable for elucidating the functional consequences of SPIRE1 loss.

A distinguishing advantage of our SPIRE1 Gene Knockout Cell Lines is their validated genetic modification, which ensures reproducibility and reliability in experimental outcomes compared to commonly used alternatives. These lines have been extensively characterized to confirm effective knockout and maintain consistent growth patterns, offering researchers confidence in their experimental designs.

Investing in the SPIRE1 Gene Knockout Cell Lines enables researchers and clinicians to contribute to the advancement of genetic research and therapeutic strategies. The deep understanding of gene function offered by our products makes them a crucial part of innovative scientific approaches. Our company specializes in providing high-quality biological products, backed by rigorous scientific expertise and a commitment to facilitating groundbreaking research in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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