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SPART Knockout Cell Lines

Gene: SPART

Official Full Name: spartinprovided by HGNC

Gene Summary: This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29851 SPART Knockout cell line (HeLa) Human SPART 1:3~1:6 Negative Online Inquiry
KO29852 SPART Knockout cell line (HEK293) Human SPART 1:3~1:6 Negative Online Inquiry
KO29853 SPART Knockout cell line (A549) Human SPART 1:3~1:4 Negative Online Inquiry

Background

SPART Gene Knockout Cell Lines are expertly engineered cellular models designed to facilitate the study of gene function and the biological mechanisms underlying a range of diseases. These cell lines are generated through the use of advanced CRISPR-Cas9 technology, allowing for precise genome editing that results in the complete removal of the SPART gene. By creating loss-of-function models, researchers can gain critical insights into the physiological roles of the SPART gene, making these cell lines invaluable for studying metabolic regulation, cellular signaling, and the pathophysiology of conditions such as obesity and diabetes.

The key functionality of SPART Gene Knockout Cell Lines lies in their ability to mimic certain pathological conditions, providing a controlled environment for experimental manipulation. When researchers utilize these knockout lines, they can examine the consequences of SPART gene disruption on cellular processes including energy homeostasis, lipogenesis, and mitochondrial function. This enables the identification of novel therapeutic targets and the refinement of disease models in both in vitro and in vivo studies.

Scientifically, the importance of SPART Gene Knockout Cell Lines extends to their applications in academic research and clinical settings. These models can significantly speed up the process of drug discovery by allowing researchers to quickly assess the effects of potential therapeutic compounds on SPART-related pathways. Additionally, they can be utilized in screening assays to identify modulators that could restore normal cellular function in the presence of SPART gene knockout.

Compared to alternative models such as wild-type cell lines, the SPART Gene Knockout Cell Lines provide a more relevant biological context that can lead to more meaningful results. Their specificity and the sophistication of the genetic modification ensure that researchers can confidently attribute observed phenotypic outcomes directly to SPART gene disruption.

This product holds substantial value for researchers, clinicians, and pharmaceutical developers who are looking to uncover the complexities of gene interactions and their implications in disease. Utilizing these cell lines can enhance the rigor and relevance of experimental findings, ultimately advancing our understanding of gene function in health and disease.

Our company is committed to delivering high-quality biological products tailored to the needs of modern research. With a robust portfolio and expertise in genetic engineering, we support the scientific community in driving innovations that lead to improved health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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