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SPAG9 Knockout Cell Lines

Gene: SPAG9

Official Full Name: sperm associated antigen 9provided by HGNC

Gene Summary: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04455 SPAG9 Knockout cell line (HeLa) Human SPAG9 1:3~1:6 Negative Online Inquiry
KO04456 SPAG9 Knockout cell line (HCT 116) Human SPAG9 1:2~1:4 Negative Online Inquiry
KO04457 SPAG9 Knockout cell line (HEK293) Human SPAG9 1:3~1:6 Negative Online Inquiry
KO04458 SPAG9 Knockout cell line (A549) Human SPAG9 1:3~1:4 Negative Online Inquiry

Background

SPAG9 Gene Knockout Cell Lines are specialized biological models that have been engineered to lack the Spag9 gene, which plays a crucial role in the formation and function of sperm flagella. This gene is associated with the production of specific proteins that are vital for motility and reproductive success. By utilizing these knockout cell lines, researchers can investigate the functional implications of Spag9 deficiency on cellular mechanisms, particularly in studies related to fertility, developmental biology, and cellular signaling.

These cell lines are created through advanced gene-editing techniques such as CRISPR-Cas9, allowing for precise alterations to the genome. As a result, SPAG9 Gene Knockout Cell Lines enable scientists to explore the functional consequences of the absence of this gene, leading to insights into its role in spermatogenesis and motility. These insights are particularly valuable in understanding male infertility, with potential applications in developing new therapeutic strategies.

The scientific importance of these cell lines extends into both research and clinical settings. They serve as invaluable tools for drug discovery, genetic studies, and the development of fertility treatments. Researchers can use these models to screen for compounds that may restore function or compensate for the loss of Spag9 activity. Compared to alternative models, which may not fully replicate the human physiological context or may involve broader genomic alterations, SPAG9 Gene Knockout Cell Lines provide a more targeted study of its specific effects, thus yielding clearer, more actionable results.

In offering these specialized cell lines, our company leverages extensive expertise in genetic engineering and cell biology. We are committed to providing high-quality, reproducible biological products that enable research breakthroughs and foster innovations in medical science. By incorporating SPAG9 Gene Knockout Cell Lines into your research toolkit, you gain access to cutting-edge tools that encapsulate precision and reliability, ultimately enhancing the scope and depth of your scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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