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SP140 Knockout Cell Lines

Gene: SP140

Official Full Name: SP140 nuclear body proteinprovided by HGNC

Gene Summary: This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31001 SP140 Knockout cell line (HCT 116) Human SP140 1:2~1:4 Negative Online Inquiry

Background

SP140 Gene Knockout Cell Lines are a cutting-edge biological tool designed to facilitate comprehensive genetic research and functional studies. These cell lines have been engineered to possess targeted deletions of the SP140 gene, which is known to play a critical role in the immune response and other physiological processes. By removing this gene, researchers can investigate its contributions to various cellular functions, disease mechanisms, and therapeutic targets, enabling a deeper understanding of its role in health and disease.

The key function of SP140 Gene Knockout Cell Lines lies in their ability to mimic specific pathological conditions resulting from the absence of SP140, providing a valuable platform for functional assays. Mechanistically, these cell lines allow for the evaluation of downstream signaling pathways, cellular interactions, and gene expression changes associated with SP140 deficiency. This is particularly relevant in exploring autoimmune diseases, cancers, and other conditions where SP140 is implicated, as it allows researchers to dissect the underlying genetic and biochemical frameworks.

The scientific importance of these cell lines transcends basic research; they have significant applications in drug discovery and therapeutic development, enabling the identification of potential drug targets and the assessment of treatment efficacy. Their ability to streamline experiments while yielding reproducible data makes them indispensable in both academic and clinical laboratories.

Compared to traditional knockout models, SP140 Gene Knockout Cell Lines offer notable advantages, such as reduced time and resource investment, improved consistency in experimental outcomes, and the capacity to conduct high-throughput screening. This positions them as a superior alternative for researchers seeking robust models with fewer variables influencing experimental results.

Ultimately, the SP140 Gene Knockout Cell Lines are invaluable tools for researchers and clinicians aiming to unlock the complexities of genetic regulation and develop novel therapeutic strategies. With our company’s commitment to excellence and innovation in biological research products, we ensure that our offerings not only meet the highest scientific standards but also empower our users with the tools they need to advance their work effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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