Gene: SNX15
Official Full Name: sorting nexin 15provided by HGNC
Gene Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26964 | SNX15 Knockout cell line (HeLa) | Human | SNX15 | 1:3~1:6 | Negative | Online Inquiry |
KO26965 | SNX15 Knockout cell line (HCT 116) | Human | SNX15 | 1:2~1:4 | Negative | Online Inquiry |
KO26966 | SNX15 Knockout cell line (HEK293) | Human | SNX15 | 1:3~1:6 | Negative | Online Inquiry |
KO26967 | SNX15 Knockout cell line (A549) | Human | SNX15 | 1:3~1:4 | Negative | Online Inquiry |
SNX15 Gene Knockout Cell Lines are invaluable biological tools designed for the study of the SNX15 gene, a crucial component in cellular processes such as endosomal trafficking, sorting, and signaling pathways. These cell lines have been meticulously developed using advanced CRISPR/Cas9 gene-editing technology to achieve precision knockout of the SNX15 gene, effectively eliminating its expression and allowing researchers to investigate the downstream effects of its absence on cellular behavior.
The key functions of SNX15 encompass its role in modulating the endosomal-lysosomal pathway, influencing receptor recycling, and facilitating cellular responses to external stimuli. The knockout cell lines provide a unique platform to elucidate the mechanisms underlying various cellular processes, making them particularly useful for researchers studying the pathogenesis of diseases linked to endosomal dysfunction, such as cancer and neurodegeneration.
Scientifically, these cell lines hold significant importance for both basic and applied research. They enable the exploration of gene function in a controlled environment, offering insights that can lead to the development of novel therapeutic strategies. In clinical settings, the understanding garnered from SNX15-related studies may have implications for targeted interventions in diseases where endosomal trafficking is disrupted.
Compared to alternative gene manipulation techniques, the SNX15 Gene Knockout Cell Lines stand out due to their high specificity and efficiency. Traditional methods, such as RNA interference, may result in off-target effects or incomplete knockdown, whereas CRISPR technology provides a robust solution with minimal unintended alterations to the genome.
For researchers and clinicians alike, the SNX15 Gene Knockout Cell Lines represent a cutting-edge resource that streamlines experimental design and enhances the fidelity of results. The ability to investigate the SNX15 gene's role in various processes can significantly accelerate discoveries in molecular and cellular biology.
Our company prides itself on its expertise in developing high-quality biological products tailored to meet the rigorous needs of the scientific community. By choosing our SNX15 Gene Knockout Cell Lines, users will gain access to a powerful tool that enhances their research capabilities and fosters advancements in understanding vital biological processes.
Please note that all services are for research use only. Not intended for any clinical use.
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