Gene: SLITRK4
Official Full Name: SLIT and NTRK like family member 4provided by HGNC
Gene Summary: This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26122 | SLITRK4 Knockout cell line (HeLa) | Human | SLITRK4 | 1:3~1:6 | Negative | Online Inquiry |
SLITRK4 Gene Knockout Cell Lines are engineered cellular models that have been specifically designed to investigate the functions of the SLITRK4 gene, which is implicated in neurodevelopmental processes and synaptic plasticity. These cell lines enable researchers to elucidate the consequences of SLITRK4 gene disruption, facilitating a deeper understanding of its role in neuronal function and its potential contributions to neuropsychiatric disorders.
The core mechanisms of SLITRK4 gene knockout involve a CRISPR-Cas9 strategy that results in precise genomic alterations. This targeted approach effectively silences the SLITRK4 gene, allowing researchers to conduct comparative studies with wild-type cells to analyze physiological and molecular changes that arise from the knockout phenotype. By using these cell lines, scientists can explore pathways related to synaptic formation and maintenance, gene expression dynamics, and neuronal signaling, thus revealing the essential functions of SLITRK4 in both health and disease.
The scientific importance of SLITRK4 Gene Knockout Cell Lines lies in their broader implications for understanding neurodevelopmental disorders such as autism spectrum disorders and schizophrenia. These cell lines can serve as invaluable tools for drug screening, biomarker discovery, and the validation of therapeutic targets, thereby enhancing translational research.
One of the key advantages of our SLITRK4 Gene Knockout Cell Lines is their high specificity and reproducibility compared to other methods, such as chemical inhibitors or broad-spectrum gene silencing techniques. This specificity allows for more accurate modeling of pathophysiological conditions, enabling researchers to obtain clearer insights into SLITRK4-related mechanisms.
For researchers and clinicians alike, our SLITRK4 Gene Knockout Cell Lines represent a significant asset in the quest for innovative therapeutic strategies and deeper biological understanding in neurodevelopmental research. They embody our commitment to delivering high-quality, impactful biological products that empower scientific exploration and advance medical research. With extensive expertise in gene editing technologies and a portfolio of innovative cellular models, our company is dedicated to supporting those at the forefront of biomedical discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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