Gene: SLIT3
Official Full Name: slit guidance ligand 3provided by HGNC
Gene Summary: The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35357 | SLIT3 Knockout cell line (A549) | Human | SLIT3 | 1:3~1:4 | Negative | Online Inquiry |
SLIT3 Gene Knockout Cell Lines are genetically engineered mammalian cell lines that have been specifically developed to lack functional SLIT3 gene expression. The SLIT3 gene encodes a member of the SLIT family of secreted proteins, which are known for their roles in cellular signaling pathways, particularly in regulating cell migration, growth, and the development of various tissues. By producing knockout cell lines, researchers can study the functional implications of SLIT3 loss in a controlled environment, elucidating its contributions to developmental biology and pathophysiology, such as neurogenesis, tumor progression, and organogenesis.
These cell lines function through the absence of SLIT3 protein, allowing for the assessment of downstream signaling cascades involved in axon guidance and cellular responses to the environment. The gene knockout results in the disruption of various cellular pathways, providing insight into the mechanisms by which SLIT3 influences cellular behavior. In clinical research, these knockout models are invaluable for investigating cancer biology, neurodevelopmental disorders, and potential therapeutic targets associated with SLIT3 signaling anomalies.
One of the key advantages of SLIT3 Gene Knockout Cell Lines is their specificity and reproducibility. Unlike siRNA-mediated knockdowns, which may exhibit off-target effects, these stable knockout lines provide a robust platform for generating consistent and reliable experimental data. Additionally, they can be used in high-throughput screening assays for drug discovery, facilitating advancements in personalized medicine.
Moreover, the scientific community recognizes the need for precise model systems in examining gene function, making SLIT3 Gene Knockout Cell Lines a critical tool for researchers focusing on gene therapy, regenerative medicine, and developmental biology. Utilizing these cell lines fosters innovation, allowing for the exploration of novel therapeutic interventions.
As a leading provider of cutting-edge biological products, our company is committed to supplying high-quality, expertly crafted gene knockout models that empower researchers to make significant advancements in their fields. With stringent quality controls and a focus on customer support, we stand ready to assist teams in their quest for scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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