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SLIT2 Knockout Cell Lines

Gene: SLIT2

Official Full Name: slit guidance ligand 2provided by HGNC

Gene Summary: This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01834 SLIT2 Knockout cell line (HeLa) Human SLIT2 1:3~1:6 Negative Online Inquiry
KO01835 SLIT2 Knockout cell line (HCT 116) Human SLIT2 1:2~1:4 Negative Online Inquiry
KO01836 SLIT2 Knockout cell line (HEK293) Human SLIT2 1:3~1:6 Negative Online Inquiry

Background

SLIT2 Gene Knockout Cell Lines are genetically modified cell lines that feature targeted deletions of the SLIT2 gene, a crucial player in cellular migration and neural guidance. These cell lines have been engineered utilizing advanced CRISPR-Cas9 genome editing technology, allowing for precise manipulation of the genetic material to study the functional consequences of SLIT2 loss.

The SLIT2 protein is integral to various physiological processes, including axon guidance in neural development and cell signaling pathways that affect angiogenesis and cancer metastasis. By utilizing these knockout cell lines, researchers can elucidate the role of SLIT2 in developmental biology, and its implications in pathological conditions such as cancer and neurodevelopmental disorders. This functional disruption provides insights into how SLIT2 modulation can affect cellular behaviors, providing a valuable tool for both in vitro and in vivo experiments.

The scientific importance of SLIT2 Gene Knockout Cell Lines extends across multiple applications, including drug discovery, developmental biology studies, and cancer research. Understanding the pathways influenced by SLIT2 can unveil therapeutic targets, making this product essential for researchers seeking to develop novel interventions.

One of the key advantages of using our SLIT2 Gene Knockout Cell Lines is the high level of specificity and efficiency achieved through our proprietary gene editing protocols, minimizing off-target effects that are common in other gene modification techniques. This precision increases the reliability of experimental outcomes, positioning our product as superior compared to traditional knockdown methodologies that utilize RNA interference.

For researchers and clinicians, the availability of these knockout cell lines represents an invaluable resource, enabling better design of experiments and fostering deeper investigations into the biological roles of SLIT2. Our commitment to quality assurance ensures that each cell line is validated for gene knockout efficiency and functional characterization, which adds an additional tier of trust for our end-users.

With extensive expertise in genetic engineering and a portfolio dedicated to innovative biological products, our company stands at the forefront of advancing research tools tailored to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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