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SLC7A14 Knockout Cell Lines

Gene: SLC7A14

Official Full Name: solute carrier family 7 member 14provided by HGNC

Gene Summary: This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissue, and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00354 SLC7A14 Knockout cell line (HeLa) Human SLC7A14 1:3~1:6 Negative Online Inquiry

Background

SLC7A14 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the sodium-dependent neutral amino acid transporter SLC7A14. This gene plays a critical role in the transport of amino acids across cell membranes, influencing various physiological processes, including cellular metabolism and signal transduction. By knocking out this gene, researchers can gain invaluable insights into the biological functions and regulatory mechanisms associated with amino acid transport, as well as their implications in diseases such as cancer and metabolic disorders.

These knockout cell lines exhibit altered cellular phenotypes, allowing for detailed studies into the functional consequences of SLC7A14 deficiency. Mechanistically, the absence of SLC7A14 can affect amino acid homeostasis, thereby impacting cellular energy production, growth trajectories, and apoptosis pathways. This functionality positions SLC7A14 knockout cell lines as essential tools in both research and clinical environments, facilitating investigations ranging from basic biology to therapeutic development.

One of the standout advantages of using SLC7A14 knockout cell lines is their potential to uncover novel therapeutic targets and strategies, particularly in areas of precision medicine focusing on metabolic diseases. Compared to traditional cell lines, these knockout models provide a more relevant biological context, mimicking the gene's effects in vivo and allowing for more predictive data in drug screening and disease modeling.

For researchers and clinicians alike, the SLC7A14 Gene Knockout Cell Lines present a unique opportunity to delve deeper into the complexities of amino acid signaling pathways, elucidating mechanisms underlying various health conditions. Their accessibility and specificity make them valuable assets for those looking to advance their understanding in the field of cellular biology.

Our company prides itself on delivering high-quality, rigorously validated biological products that support scientific advancement. With extensive expertise in genetic modifications and cellular biology, we are committed to empowering researchers with the tools they need to unlock new frontiers in their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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