Gene: SLC41A3
Official Full Name: solute carrier family 41 member 3provided by HGNC
Gene Summary: Enables magnesium:sodium antiporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrial inner membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13992 | SLC41A3 Knockout cell line (HeLa) | Human | SLC41A3 | 1:3~1:6 | Negative | Online Inquiry |
KO13993 | SLC41A3 Knockout cell line (HCT 116) | Human | SLC41A3 | 1:2~1:4 | Negative | Online Inquiry |
KO13994 | SLC41A3 Knockout cell line (HEK293) | Human | SLC41A3 | 1:3~1:6 | Negative | Online Inquiry |
KO13995 | SLC41A3 Knockout cell line (A549) | Human | SLC41A3 | 1:3~1:4 | Negative | Online Inquiry |
SLC41A3 Gene Knockout Cell Lines are genetically modified cell lines that facilitate the study of the SLC41A3 gene's functions by providing a platform where this gene is entirely disabled. The SLC41A3 gene encodes a magnesium transporter, which plays a critical role in cellular magnesium homeostasis, influencing various biological processes such as cell proliferation, energy metabolism, and stress responses. By utilizing knockout cell lines, researchers can accurately investigate the physiological consequences of the absence of SLC41A3, providing insight into its role in health and disease.
The primary mechanism of these knockout cell lines involves targeted CRISPR-Cas9 technology, where specific sequences within the SLC41A3 gene have been disrupted, leading to a loss of function. This allows for a clearer understanding of how SLC41A3 influences cellular behaviors and responses under varied experimental conditions. Studies utilizing these cell lines are crucial, particularly in cancer research, neurobiology, and metabolic disorders, where magnesium transport may significantly impact pathophysiology.
The scientific importance of SLC41A3 Gene Knockout Cell Lines cannot be overstated. They serve as valuable models for pharmacological testing, allowing for the evaluation of drug efficacy and toxicity in cells lacking this crucial transporter. Compared to traditional methods, these knockout models offer higher specificity and control over genetic variables, increasing reproducibility and reliability in experimental outcomes.
What sets our SLC41A3 Gene Knockout Cell Lines apart from competitors is our commitment to quality and user-friendliness. Each cell line comes extensively validated for knockout efficiency and specificity, ensuring researchers obtain precise results. Furthermore, our lines are compatible with a wide range of assays, making them versatile tools in a laboratory setting.
For researchers and clinicians aiming to deepen their understanding of magnesium's role in cellular functions and its implications in various diseases, SLC41A3 Gene Knockout Cell Lines present an invaluable resource. Our company brings years of expertise in genetic engineering and product development, ensuring we deliver not only high-quality biological products but also optimal support for our users in their quest for scientific advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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