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SLC36A1 Knockout Cell Lines

Gene: SLC36A1

Official Full Name: solute carrier family 36 member 1provided by HGNC

Gene Summary: This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33426 SLC36A1 Knockout cell line (HeLa) Human SLC36A1 1:3~1:6 Negative Online Inquiry
KO33427 SLC36A1 Knockout cell line (HCT 116) Human SLC36A1 1:2~1:4 Negative Online Inquiry
KO33428 SLC36A1 Knockout cell line (HEK293) Human SLC36A1 1:3~1:6 Negative Online Inquiry
KO33429 SLC36A1 Knockout cell line (A549) Human SLC36A1 1:3~1:4 Negative Online Inquiry

Background

SLC36A1 Gene Knockout Cell Lines are specialized cellular models that have been genetically modified to disrupt the function of the SLC36A1 gene, which encodes a high-affinity proton-coupled transporter implicated in amino acid transport. This innovative product enables researchers to investigate the physiological and pathological roles of SLC36A1 in various biological contexts. By creating a cellular environment devoid of SLC36A1, these knockout lines facilitate the study of amino acid homeostasis, cellular metabolism, and the impact of SLC36A1 deficiency on disease processes.

The primary function of these knockout cell lines lies in their ability to elucidate the mechanisms by which SLC36A1 influences cellular functions. Researchers can explore various aspects such as membrane transport dynamics, nutrient sensing, and signal transduction pathways in conditions mimicking physiological and pathological states. This provides valuable insights into metabolic disorders, cancer biology, and neurological functions, where SLC36A1 participates in critical processes.

From a scientific standpoint, SLC36A1 Gene Knockout Cell Lines are essential for advancing our understanding of amino acid transport mechanisms and their implications in human health. They serve as powerful tools in drug discovery, toxicology studies, and genetic research, particularly for conditions where amino acid transport is disrupted.

What sets these knockout cell lines apart from other genetic models is their specificity and reliable knockout efficiency, ensuring that researchers can achieve reproducible and interpretable results. Unlike traditional models, which may exhibit compensatory mechanisms or residual activity, our SLC36A1 knockout lines provide a more accurate representation of the gene's functional absence.

For researchers and clinicians alike, this product offers the unique advantage of facilitating targeted studies with the intention to develop novel therapeutic strategies against diseases linked to amino acid dysregulation. With our extensive expertise in genetic engineering and cell line development, we are committed to providing high-quality biological products that enhance research capabilities and foster innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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