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SLC30A7 Knockout Cell Lines

Gene: SLC30A7

Official Full Name: solute carrier family 30 member 7provided by HGNC

Gene Summary: Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05821 SLC30A7 Knockout cell line (HeLa) Human SLC30A7 1:3~1:6 Negative Online Inquiry
KO05822 SLC30A7 Knockout cell line (HCT 116) Human SLC30A7 1:2~1:4 Negative Online Inquiry
KO05823 SLC30A7 Knockout cell line (HEK293) Human SLC30A7 1:3~1:6 Negative Online Inquiry
KO05824 SLC30A7 Knockout cell line (A549) Human SLC30A7 1:3~1:4 Negative Online Inquiry

Background

SLC30A7 Gene Knockout Cell Lines are meticulously engineered cell models that have undergone precise genetic modification to disable the SLC30A7 gene, which encodes a zinc transporter critical for maintaining cellular zinc homeostasis. By utilizing CRISPR-Cas9 genome editing technology, these cell lines ensure a high degree of specificity and efficiency in knocking out the gene of interest, making them invaluable tools for studying the role of zinc in various biological processes and diseases.

The key mechanism behind SLC30A7 knockout is the disruption of zinc transport, which impacts intracellular zinc levels and subsequently influences numerous signaling pathways, metabolic processes, and cellular functions. These cell lines allow researchers to elucidate the functional implications of zinc dysregulation in cellular contexts, providing insights into diseases such as diabetes, neurodegenerative disorders, and cancer.

The scientific importance of SLC30A7 Gene Knockout Cell Lines extends to both research and clinical applications. In research settings, they serve as robust platforms for drug discovery, toxicology studies, and the exploration of zinc's role in pathology. Clinically, understanding SLC30A7's function may inform therapeutic strategies aimed at modulating zinc levels or signaling in diverse health conditions.

Compared to alternative knockout models, SLC30A7 Gene Knockout Cell Lines offer superior specificity, reproducibility, and functionality, as they are generated from robust cell line backgrounds that are amenable to a variety of assays. This specificity reduces the risk of off-target effects and enhances the reliability of experimental outcomes, making them an optimal choice for rigorous scientific investigations.

For researchers and clinicians, the value of these cell lines lies in their capability to provide clear, interpretable data related to zinc dynamics, potentially guiding novel therapeutic approaches and advancing our understanding of zinc's essential roles in biology. Our commitment to quality and innovation underpins our expertise in producing high-standard biological products like SLC30A7 Gene Knockout Cell Lines, positioning us as a trusted partner in the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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