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SLC26A1 Knockout Cell Lines

Gene: SLC26A1

Official Full Name: solute carrier family 26 member 1provided by HGNC

Gene Summary: This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31455 SLC26A1 Knockout cell line (HCT 116) Human SLC26A1 1:2~1:4 Negative Online Inquiry
KO31456 SLC26A1 Knockout cell line (HEK293) Human SLC26A1 1:3~1:6 Negative Online Inquiry

Background

SLC26A1 Gene Knockout Cell Lines represent a cutting-edge tool utilized in molecular biology for the study of the SLC26A1 gene, known for its role in transporting anions and mediating various physiological functions. These specialized cell lines have had the SLC26A1 gene removed or inactivated through targeted gene editing techniques, such as CRISPR-Cas9, thereby creating a unique platform for investigating the biological implications of this gene’s absence.

The key function of SLC26A1 Gene Knockout Cell Lines lies in their ability to elucidate the pathways and mechanisms regulated by the SLC26A1 gene. By comparing the knockout cell lines to their wild-type counterparts, researchers can gain insights into the gene's role in cellular homeostasis, ion transport, and potential pathophysiological conditions, such as hearing loss or metabolic disorders. The ability to manipulate these cell lines facilitates the identification of novel therapeutic targets and the development of innovative treatment strategies.

In research and clinical settings, these cell lines are invaluable for dissecting the molecular underpinnings of diseases linked to dysfunctional anion transporters. They can be employed in drug screening assays, where the effects of candidate compounds on the modified cells can be evaluated, thereby accelerating the translation of basic research into clinical applications.

The unique advantages of SLC26A1 Gene Knockout Cell Lines stem from their specificity and reliability when compared to alternative models, such as transgenic animals or unmodified cell lines. They provide a more controllable environment for experimentation, reducing variability and allowing for focused studies on the SLC26A1 gene’s effects without confounding factors from other genes.

Researchers and clinicians benefit from incorporating these cell lines into their studies because they enhance the understanding of genetic disorders and pave the way for advancements in targeted therapies. The precise manipulation of genetic material offered by our SLC26A1 Gene Knockout Cell Lines positions them as a vital asset in both academic research and pharmaceutical development.

Our company specializes in providing high-quality biological products, and we are committed to advancing the field of molecular biology through innovative solutions that empower researchers and clinicians in their quest for knowledge and therapeutic breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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