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SLC25A53 Knockout Cell Lines

Gene: SLC25A53

Official Full Name: solute carrier family 25 member 53provided by HGNC

Gene Summary: Predicted to enable NAD transmembrane transporter activity. Predicted to be involved in NAD transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21341 SLC25A53 Knockout cell line (HeLa) Human SLC25A53 1:3~1:6 Negative Online Inquiry
KO21342 SLC25A53 Knockout cell line (HCT 116) Human SLC25A53 1:2~1:4 Negative Online Inquiry
KO21343 SLC25A53 Knockout cell line (HEK293) Human SLC25A53 1:3~1:6 Negative Online Inquiry
KO21344 SLC25A53 Knockout cell line (A549) Human SLC25A53 1:3~1:4 Negative Online Inquiry

Background

SLC25A53 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to facilitate the study of the SLC25A53 gene, which encodes a critical mitochondrial transporter implicated in various metabolic processes. By employing CRISPR-Cas9 technology, these cell lines have been rendered deficient in SLC25A53 function, thus providing a valuable model for understanding the gene's influence on mitochondrial dynamics and cellular metabolism.

The key function of the SLC25A53 gene centers around its role in transporting specific metabolites across the mitochondrial membrane, thereby influencing energy production and reactive oxygen species regulation. By utilizing these knockout cell lines, researchers can elucidate the pathways affected by SLC25A53 deficiency, enabling them to investigate the potential ties to mitochondrial disorders and other metabolic diseases. This detailed mechanistic understanding is vital for advancing therapeutic approaches targeting mitochondrial dysfunction.

Scientifically, SLC25A53 Gene Knockout Cell Lines serve as an essential tool in both basic and applied research settings. Their applications range from assessing the impact of SLC25A53 on cellular respiration to examining therapeutic interventions aimed at mitochondrial diseases. By providing a controlled environment for in-depth experimentation, these cell lines empower researchers to discover novel insights and develop targeted treatments.

Compared to traditional methods involving whole animal models or unmodified human cell lines, SLC25A53 Gene Knockout Cell Lines offer specificity, reproducibility, and improved regulatory oversight. These knockout lines allow for precise phenotypic characterization and functional assays, streamlining the research process and yielding robust data that can support the development of breakthrough therapies.

The significance of SLC25A53 Gene Knockout Cell Lines extends beyond their research applications; they are an invaluable asset to clinicians seeking to better understand the genetic underpinnings of mitochondrial disease. With the continued growth of personalized medicine, these cell lines contribute to the future of tailored therapeutic strategies.

Our company specializes in providing high-quality, genetically engineered cell lines designed for innovative research. With our commitment to advancing the understanding of complex biological systems, we ensure that our products meet the highest standards of performance and reliability, enabling researchers and clinicians alike to achieve their goals.

Please note that all services are for research use only. Not intended for any clinical use.

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