Gene: SLC17A3
Official Full Name: solute carrier family 17 member 3provided by HGNC
Gene Summary: The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31526 | SLC17A3 Knockout cell line (A549) | Human | SLC17A3 | 1:3~1:4 | Negative | Online Inquiry |
SLC17A3 Gene Knockout Cell Lines are specialized cellular models created by the targeted inactivation of the SLC17A3 gene, which encodes for a member of the solute carrier family involved in neurotransmitter transport. By employing CRISPR-Cas9 gene editing technology, our SLC17A3 knockout cell lines provide researchers with invaluable tools for elucidating the functional role of this gene in various biological processes, including the regulation of ion balance and cellular signaling pathways.
The primary function of these cell lines is to allow for the detailed study of SLC17A3's involvement in neurotransmitter homeostasis and its implications in neurobiology. By examining the phenotypic changes that occur in the absence of this transporter, researchers can better understand its contribution to conditions such as epilepsy, neurodegeneration, and other synaptic dysfunctions. Moreover, these cell lines facilitate investigations into molecular mechanisms underlying drug action and toxicity related to neurotransmitter transport.
The scientific significance of SLC17A3 knockout cell lines is profound, ascending from basic research to potential clinical applications. These models can serve as platforms for drug discovery, enabling the screening of pharmacological agents that might modulate neurotransmitter levels. The ability to study specific transport mechanisms in a controlled environment underscores their utility in translational research.
What sets our SLC17A3 knockout cell lines apart from alternative products is their stringent validation through comprehensive genotyping and functional assays, ensuring researchers receive highly reliable models tailored to their experimental needs. Additionally, our expert team provides dedicated support, assisting users in experimental design and application to maximize the utility of the cell lines.
Valuable to researchers, clinicians, and pharmacologists alike, our SLC17A3 Gene Knockout Cell Lines are designed to accelerate discoveries in neurobiology, ultimately paving the way for innovative therapeutic strategies. Our company prides itself on its commitment to quality and expertise in biological product development, ensuring that each offering is equipped to meet and exceed the demands of modern research.
Please note that all services are for research use only. Not intended for any clinical use.
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