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SLC15A4 Knockout Cell Lines

Gene: SLC15A4

Official Full Name: solute carrier family 15 member 4provided by HGNC

Gene Summary: Enables several functions, including L-histidine transmembrane transporter activity; peptide:proton symporter activity; and peptidoglycan transmembrane transporter activity. Involved in dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of pattern recognition receptor signaling pathway. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00437 SLC15A4 Knockout cell line (HeLa) Human SLC15A4 1:3~1:6 Negative Online Inquiry
KO29652 SLC15A4 Knockout cell line (HCT 116) Human SLC15A4 1:2~1:4 Negative Online Inquiry
KO29653 SLC15A4 Knockout cell line (HEK293) Human SLC15A4 1:3~1:6 Negative Online Inquiry
KO29654 SLC15A4 Knockout cell line (A549) Human SLC15A4 1:3~1:4 Negative Online Inquiry

Background

SLC15A4 Gene Knockout Cell Lines are genetically engineered cell cultures designed to lack the expression of the SLC15A4 gene, which encodes for a protein involved in the transport of small peptides and other solutes across cellular membranes. This specific modification enables researchers to study the role and significance of SLC15A4 in various biological processes, including immune responses, nutrient uptake, and metabolic regulation. By utilizing these knockout cell lines, scientists can investigate the molecular mechanisms underlying diseases and conditions associated with altered peptide transport, ultimately leading to the identification of potential therapeutic targets.

The primary functionality of SLC15A4 Gene Knockout Cell Lines lies in their enablement of comparative studies between normal and knockout cellular functions. The absence of the SLC15A4 protein alters cellular responses to various stimuli, allowing researchers to observe changes in cellular metabolism, signaling pathways, and gene expression profiles. This knockout model is particularly valuable in the context of immunology and infectious diseases, where the transport of peptides can influence immune cell activation and response to pathogens.

From a scientific standpoint, these cell lines serve as powerful tools for elucidating the biological roles of SLC15A4 in health and disease. Their applications range from basic research, where they contribute to foundational understanding of cellular mechanisms, to potential clinical implications in drug discovery and disease modeling. By providing insights into how peptide transport affects various physiological and pathological states, these cell lines can ultimately aid in the development of novel therapeutic strategies.

Compared to wild-type cell lines or other gene-editing alternatives such as CRISPR-based models, SLC15A4 Gene Knockout Cell Lines offer precise and stable genetic modifications without the complexities associated with off-target effects. This ensures that data derived from experiments is reliable and reproducible, significantly increasing the robustness of experimental outcomes.

For researchers and clinicians focused on the immunological roles of peptide transport and its implications in various diseases, SLC15A4 Gene Knockout Cell Lines represent a unique resource that facilitates advanced studies. This product is indispensable for those aiming to develop a deeper understanding of peptide-mediated biological functions.

Our company specializes in the development and supply of innovative biological products that empower scientific research. With rigorous quality control and a commitment to advancing laboratory capabilities, our offerings ensure that researchers can trust the integrity and utility of their experimental models.

Please note that all services are for research use only. Not intended for any clinical use.

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